Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pafah1b3tm1Cla targeted mutation 1, Gary D Clark MGI:2665018 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• gene product is not required for embryonic and early postnatal development
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| N |
• both males and females fertile
• testis weight essentially equal to that of wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Testicular phenotypes of mice having various combinations of Pafah1b1tm1Awb, Pafah1b2Gt(Betageo)1Cla and Pafah1b3tm1Cla alleles
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• germ cell depletion is more severe than in the single Pafah1b2 homozygote
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• multinucleated giant cells are seen in the seminiferous epithelium
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• testis tubular structures are less obvious and the lumen is small
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• testis weigh about 30% of that of control mice
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• disruption occurs at the initiation phase of spermatogenesis
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• males are infertile, however female fertility is unaffected
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• testis tubular structures are less obvious and the lumen is small
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• testis weigh about 30% of that of control mice
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• germ cell depletion is more severe than in the single Pafah1b2 homozygote
|
|
|
• multinucleated giant cells are seen in the seminiferous epithelium
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Testicular phenotypes of mice having various combinations of Pafah1b1tm1Awb, Pafah1b2Gt(Betageo)1Cla and Pafah1b3tm1Cla alleles
| N |
• males are fertile
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• some degenerating germ cells are seen
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• occasional multinucleated giant cells are seen in the seminiferous epithelium
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• testis weigh about 20% less than that of control mice
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• some degenerating germ cells are seen
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• occasional multinucleated giant cells are seen in the seminiferous epithelium
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• testis weigh about 20% less than that of control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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