Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-Abl1)40Sco
• Allele Name: transgene insertion 40, Suzanne Cory
• Allele ID: MGI:2665029
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Igh-Abl1)40Sco/0 Tg(IghMyc)22Bri/0	involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi	MGI:2665034
tg2	Tg(Igh-Abl1)40Sco/0	involves: C57BL/6JWehi * SJL/JWehi	MGI:2665033

Genotype
MGI:2665034

cx1

• Allelic Composition: Tg(Igh-Abl1)40Sco/0; Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased plasmacytoma incidence ( J:78204 )

• accelerated development of plasmacytomas compared to single Tg(Igh-Abl1)40Sco transgenic mice, with mice becoming ill between 5 and 8 weeks of age; especially prominent in the intestine

• tumors are oligoclonal and often secrete IgM

• however, double transgenics do not develop pre-B or B lymphomas, as observed in single Tg(IghMyc)22Bri mice

immune system

enlarged mesenteric lymph nodes ( J:78204 )

• 64% of transgenics exhibit enlarged mesenteric lymph nodes due to engorgement with plasmacytoma cells

Genotype
MGI:2665033

tg2

• Allelic Composition: Tg(Igh-Abl1)40Sco/0
• Genetic Background: involves: C57BL/6JWehi * SJL/JWehi

neoplasm

increased plasmacytoma incidence ( J:78204 )

• develop plasmacytomas, with 60% of mutants becoming ill between 11 and 52 weeks of age

• plasmacytomas are clonal and secrete IgA or IgG

immune system

enlarged spleen ( J:78204 )

• seen in 42% of mutants

enlarged mesenteric lymph nodes ( J:78204 )

• seen in 85% of mutants

abnormal peripheral lymph node morphology ( J:78204 )

• 23% of mutants exhibit enlarged peripheral lymph nodes

hematopoietic system

enlarged spleen ( J:78204 )

• seen in 42% of mutants

homeostasis/metabolism

ascites ( J:78204 )

• 27% of mutants exhibit peritoneal ascites

growth/size/body

enlarged spleen ( J:78204 )

• seen in 42% of mutants