Analysis Tools|
Allele Symbol Allele Name Allele ID |
Btctm1Dcl targeted mutation 1, David C Lee MGI:2665044 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes are viable, fertile and healthy with no significant differences in pancreas or cardiac valve morphology and a normal response to a glucose challenge test
• neither left atrial dilation and thrombosis nor cardiac fibrosis or ectopic cartilage formation are observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 54% of double homozygotes die by 4 months of age while 83% are found dead within the first year, indicating a further reduction in lifespan relative to single Hbegftm1Dcl homozygotes
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• newborn double homozygotes display enlarged atrioventricular valves
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• adult double homozygotes exhibit left atrial dilation, rarely or never observed in single Hbegftm1Dcl homozygotes
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• newborn double homozygotes display enlarged semilunar valves
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• newborn double homozygotes display enlarged aortic valves; however, the mean aortic valve area of double mutants is not significantly different from that of single Hbegftm1Dcl homozygotes
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• at ~2 months, moribund double homozygotes exhibit extensive intraventricular or focal epicardial fibrosis within or on the left ventricle, rarely or never observed in single Hbegftm1Dcl homozygotes
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• at 4 months, male double homozygotes exhibit reduced fractional shortening (58.8 +/- 15.9) relative to wild-type males (71.8 +/- 3.3), indicating significant systolic dysfunction
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• at 4 months, male double homozygotes exhibit reduced fractional shortening (58.8 +/- 15.9) relative to wild-type males (71.8 +/- 3.3), indicating significant systolic dysfunction
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• adult double homozygotes exhibit left atrial thrombosis, rarely or never observed in single Hbegftm1Dcl homozygotes
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• at 4 months, male double homozygotes exhibit a reduced body weight (29.0 +/- 2.5) relative to wild-type males (33.6 +/- 2.8 g)
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• double homozygotes display chondrocytes and ectopic cartilage formation throughout the aortic valve leaflets, similar to single Hbegftm1Dcl homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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