All Phenotypes Pde6b<rd1-2J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pde6b^rd1-2J
retinal degeneration 1, 2 Jackson
MGI:2665102

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde6b^rd1-2J/Pde6b^rd1-2J	C57BL/6J-Pde6b^rd1-2J/J	MGI:2665106
cx2	Pde6a^nmf363/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺	C57BL/6J-Pde6b^rd1-2J Pde6a^nmf363	MGI:3828997
cx3	Pde6a^nmf282/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺	involves: A/J * C57BL/6J	MGI:3828996

Allelic Composition	Pde6b^rd1-2J/Pde6b^rd1-2J
Genetic Background	C57BL/6J-Pde6b^rd1-2J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6b^rd1-2J mutation (1 available); any Pde6b mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:122722 )

• white retinal vessels are clinically observed at 24 days of age

retina degeneration ( J:122722 )

• indirect opthalmoscopic examination reveals a mottled retina by 24 days of age, indicative of retinal degeneration

• histological analysis demonstrates extensive degeneration of the outer nuclear layer of the retina by 16 days of age and no outer nuclear layer remaining by 30 days of age

abnormal eye electrophysiology ( J:122722 )

• electroretinogram recordings reveal that homozygotes show no detectable rod or cone responses at any age

cardiovascular system

abnormal retina vasculature morphology ( J:122722 )

• white retinal vessels are clinically observed at 24 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital stationary night blindness autosomal dominant 2		DOID:0110863	OMIM:163500	J:82238

Allelic Composition	Pde6a^nmf363/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺
Genetic Background	C57BL/6J-Pde6b^rd1-2J Pde6a^nmf363

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6a^nmf363 mutation (0 available); any Pde6a mutation (52 available)
Pde6b^rd1-2J mutation (1 available); any Pde6b mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:142108 )

N	• a and b wave response is normal at 5 to 6 months of age

Allelic Composition	Pde6a^nmf282/Pde6a⁺ Pde6b^rd1-2J/Pde6b⁺
Genetic Background	involves: A/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6a^nmf282 mutation (1 available); any Pde6a mutation (52 available)
Pde6b^rd1-2J mutation (1 available); any Pde6b mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:142108 )

N	• a and b wave response is normal at 5 to 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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