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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mark2Gt(pSABetageo)38Bss
gene trap 38, Stephanie Bessone
MGI:2665175
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mark2Gt(pSABetageo)38Bss/Mark2Gt(pSABetageo)38Bss involves: 129S2/SvPas * MF1 MGI:2665277
ht2
Mark2Gt(pSABetageo)38Bss/Mark2+ involves: 129S2/SvPas * MF1 MGI:2665279


Genotype
MGI:2665277
hm1
Allelic
Composition
Mark2Gt(pSABetageo)38Bss/Mark2Gt(pSABetageo)38Bss
Genetic
Background
involves: 129S2/SvPas * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mark2Gt(pSABetageo)38Bss mutation (0 available); any Mark2 mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system

endocrine/exocrine glands
• reduced size
• 64% reduction in weight relative to wild-type, 6 to 7 weeks of age
• no weight difference relative to wild-type between 3 and 4 weeks of age
• 50% reduction in weight relative to wild-type
• 23% reduction in weight relative to wild-type, 6 to 7 weeks of age
• no weight difference relative to wild-type between 3 and 4 weeks of age

growth/size/body
• reduced weight was first observed at E16.5 and first significant at E18.5, at which point there was 10% reduction relative to wild-type
• body weights, relative to wild-type, were reduced by 24% at birth and 31% at 3 weeks of age
• increased size

homeostasis/metabolism
• reduced in females by 71% (4 weeks) and 53% (12 weeks) in the pituitary
• no reduction was observed in male mice

reproductive system
• 64% reduction in weight relative to wild-type, 6 to 7 weeks of age
• no weight difference relative to wild-type between 3 and 4 weeks of age
• 50% reduction in weight relative to wild-type
• 23% reduction in weight relative to wild-type, 6 to 7 weeks of age
• no weight difference relative to wild-type between 3 and 4 weeks of age
• 64% reduction in weight relative to wild-type
• 50% reduction in weight relative to wild-type, 6 to 7 weeks of age
• no weight difference relative to wild-type between 3 and 4 weeks of age
• observed in crosses between mutant females and wild-type males
• no offspring yielded by intercrossing

respiratory system
• increased size

nervous system
• reduced size




Genotype
MGI:2665279
ht2
Allelic
Composition
Mark2Gt(pSABetageo)38Bss/Mark2+
Genetic
Background
involves: 129S2/SvPas * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mark2Gt(pSABetageo)38Bss mutation (0 available); any Mark2 mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weights, relative to wild-type, were reduced by 6% at 3 weeks of age and 16% at 8 weeks of age





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory