Analysis Tools
mortality/aging
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• most mutants die within 1 week after birth, although survival is prolonged to 8-20 days in 10% of pups compared to single Insr homozygotes
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adipose tissue
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• adipose tissue in the inguinal region is underdeveloped in longer surviving pups
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growth/size/body
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• pups surviving 8-20 days are smaller
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• pups surviving 8-20 days weight 40-60% less than wild-type littermates at P10 and P17, respectively
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homeostasis/metabolism
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• pups with early diabetic ketoacidosis exhibit a 6-fold increase in serum glucose levels, however this level is less than in single Insr homozygotes
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• pups with early diabetic ketoacidosis exhibit extremely reduced hepatic glycogen levels
• however, pups with no ketoacidosis have almost normal glycogen levels
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• 26/240 pups exhibit glycosuria, however development is delayed by more than a week compared to single Insr homozygotes
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• pups with early diabetic ketoacidosis exhibit a 2.5-fold increase in triglyceride levels
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ketoaciduria
(
J:80773
)
|
• 26/240 pups develop ketoacidosis, although development is delayed by more than a week compared to single Insr homozygotes
|
liver/biliary system
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• pups with early diabetic ketoacidosis exhibit extremely reduced hepatic glycogen levels
• however, pups with no ketoacidosis have almost normal glycogen levels
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• pups with early diabetic ketoacidosis exhibit hepatic steatosis, although development is delayed by more than a week compared to single Insr homozygotes
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renal/urinary system
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• 26/240 pups exhibit glycosuria, however development is delayed by more than a week compared to single Insr homozygotes
|
ketoaciduria
(
J:80773
)
|
• 26/240 pups develop ketoacidosis, although development is delayed by more than a week compared to single Insr homozygotes
|
