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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tcra,Tcrb)3Ayr
transgene insertion 3, Alexander Y Rudensky
MGI:2665469
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Tcra,Tcrb)3Ayr/0 involves: C57BL/6 * DBA/2 MGI:2665511


Genotype
MGI:2665511
tg1
Allelic
Composition		 Tg(Tcra,Tcrb)3Ayr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra,Tcrb)3Ayr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:80775 )
• actively proliferating cells are lower in number than proliferating control cells
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice
abnormal lymphocyte anergy ( J:80775 )
• cells are hyporesponsive to antigenic peptide challenge

hematopoietic system
decreased T cell proliferation ( J:80775 )
• actively proliferating cells are lower in number than proliferating control cells
abnormal positive T cell selection ( J:125548 )
• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

cellular
decreased T cell proliferation ( J:80775 )
• actively proliferating cells are lower in number than proliferating control cells




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory