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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh23Ahl+
wild-type of age related hearing loss
MGI:2665714
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdh23Ahl+/Cdh23Ahl+
Tbc1d24em4Tbf/Tbc1d24em4Tbf 		B6.Cg-Cdh23Ahl+ Tbc1d24em4Tbf MGI:6490586
cx2
 		Cdh23Ahl+/Cdh23Ahl+
Ush2atm1Tili/Ush2atm1Tili 		involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ MGI:3702270


Genotype
MGI:6490586
cx1
Allelic
Composition		 Cdh23Ahl+/Cdh23Ahl+
Tbc1d24em4Tbf/Tbc1d24em4Tbf
Genetic
Background		 B6.Cg-Cdh23Ahl+ Tbc1d24em4Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23Ahl+ mutation (4 available); any Cdh23 mutation (281 available)
Tbc1d24em4Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:299025 )
N
• mice exhibit normal hearing, auditory brainstem response thresholds at P30, P60, and P90, wave 1 latencies and amplitudes, and distortion product otoacoustic emissions

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT autosomal dominant nonsyndromic deafness 65 DOID:0110586 OMIM:616044
 J:299025




Genotype
MGI:3702270
cx2
Allelic
Composition		 Cdh23Ahl+/Cdh23Ahl+
Ush2atm1Tili/Ush2atm1Tili
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CAST/EiJ * CBA/CaJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23Ahl+ mutation (4 available); any Cdh23 mutation (281 available)
Ush2atm1Tili mutation (0 available); any Ush2a mutation (292 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal distortion product otoacoustic emission ( J:118927 )
• at 4 months of age, mice show normal cochlear function at low frequency but an elevated threshold at higher frequencies; there was no progression when tested at 7 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory