All Phenotypes H1f4<tm2Ais> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H1f4^tm2Ais
targeted mutation 2, Arthur I Skoultchi
MGI:2665857

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm1Yhf/H1f3^tm1Yhf H1f4^tm2Ais/H1f4^tm2Ais	involves: 129 * C57BL/6 * SJL	MGI:5703969
cx2	H1f2^tm2Ais/H1f2⁺ H1f3^tm2Ais/H1f3⁺ H1f4^tm2Ais/H1f4⁺	involves: 129/Sv * C57BL/6 * SJL	MGI:2674059
cx3	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais	involves: 129/Sv * C57BL/6 * SJL	MGI:2674072
cx4	H1f2^tm2Ais/H1f2^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais	involves: 129/Sv * C57BL/6 * SJL	MGI:2674056
cx5	H1f0^tm1Ais/H1f0^tm1Ais H1f2^tm2Ais/H1f2^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais	involves: 129/Sv * C57BL/6 * SJL	MGI:2674076
cx6	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3⁺ H1f4^tm2Ais/H1f4^tm2Ais	involves: 129/Sv * C57BL/6 * SJL	MGI:2674082
cx7	H1f0^tm1Ais/H1f0^tm1Ais H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais	involves: 129/Sv * C57BL/6 * SJL	MGI:2674074

Allelic Composition	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm1Yhf/H1f3^tm1Yhf H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f2^tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f3^tm1Yhf mutation (0 available); any H1f3 mutation (8 available)
H1f4^tm2Ais mutation (0 available); any H1f4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:223052 )

• mice are viable and fertile

Allelic Composition	H1f2^tm2Ais/H1f2⁺ H1f3^tm2Ais/H1f3⁺ H1f4^tm2Ais/H1f4⁺
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f2^tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f3^tm2Ais mutation (0 available); any H1f3 mutation (8 available)
H1f4^tm2Ais mutation (0 available); any H1f4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83954 )

• triple heterozygotes are under represented in litters at birth

Allelic Composition	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83954 )

• no triple homozygotes are born

• no triple homozygous embryos after E11.5

• only about 25% as many embryos at E10.5 as expected

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:83954 )

• triple homozygotes are under represented by E7.5

cardiovascular system

absent vitelline blood vessels ( J:83954 )

• no visible blood or blood vessels at E10.5

enlarged pericardium ( J:83954 )

• at E9.5

embryo

abnormal rostral-caudal axis patterning ( J:83954 )

• arrested posterior development while anterior development remained normal at E9.5

rostral-caudal axis duplication ( J:83954 )

• partial or complete axis duplication in early somite stage embryos (n=2)

embryonic growth retardation ( J:83954 )

decreased embryo size ( J:83954 )

• embryos between E7.5 and E11.5 are reduced in size

• retarded development based on somite number

• E10.5 embryos with 16-18 somites as opposed to an expected 26-30 somites

abnormal neural tube morphology ( J:83954 )

• varied from mild to more severe (splayed anterior neural tube)

abnormal extraembryonic tissue morphology ( J:83954 )

absent vitelline blood vessels ( J:83954 )

• no visible blood or blood vessels at E10.5

abnormal visceral yolk sac morphology ( J:83954 )

pale yolk sac ( J:83954 )

failure of chorioallantoic fusion ( J:83954 )

• failed chorioallantoic fusion at E9.5

growth/size/body

embryonic growth retardation ( J:83954 )

decreased embryo size ( J:83954 )

• embryos between E7.5 and E11.5 are reduced in size

• retarded development based on somite number

• E10.5 embryos with 16-18 somites as opposed to an expected 26-30 somites

limbs/digits/tail

short tail ( J:83954 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:83954 )

• varied from mild to more severe (splayed anterior neural tube)

Allelic Composition	H1f2^tm2Ais/H1f2^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f2^tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f4^tm2Ais mutation (0 available); any H1f4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:83954 )

• males are smaller on average at postnatal day 7 and as adults

• females are of normal size

Allelic Composition	H1f0^tm1Ais/H1f0^tm1Ais H1f2^tm2Ais/H1f2^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0^tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f2^tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f4^tm2Ais mutation (0 available); any H1f4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:83954 )

• homozygotes are under represented in litters at birth

growth/size/body

decreased body size ( J:83954 )

• mice are much smaller at birth and as adults

immune system

small thymus ( J:83954 )

• histologically normal however

reproductive system

reduced fertility ( J:83954 )

• both male and female mutants are fertile when crossed to wild-type mice but display reduced fertility when crossed to one another

hematopoietic system

small thymus ( J:83954 )

• histologically normal however

endocrine/exocrine glands

small thymus ( J:83954 )

• histologically normal however

Allelic Composition	H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3⁺ H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:83954 )

• very mild shortening of life span

prenatal lethality, incomplete penetrance ( J:83954 )

• homozygotes are under represented in litters at birth

growth/size/body

decreased body size ( J:83954 )

• mice are much smaller at birth and as adults

immune system

small thymus ( J:83954 )

• histologically normal however

reproductive system

reduced fertility ( J:83954 )

• both male and female mutants are fertile when crossed to wild-type mice but display reduced fertility when crossed to one another

hematopoietic system

small thymus ( J:83954 )

• histologically normal however

endocrine/exocrine glands

small thymus ( J:83954 )

• histologically normal however

Allelic Composition	H1f0^tm1Ais/H1f0^tm1Ais H1f2^tm2Ais/H1f2^tm2Ais H1f3^tm2Ais/H1f3^tm2Ais H1f4^tm2Ais/H1f4^tm2Ais
Genetic Background	involves: 129/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f0^tm1Ais mutation (0 available); any H1f0 mutation (13 available)
H1f2^tm2Ais mutation (0 available); any H1f2 mutation (16 available)
H1f3^tm2Ais mutation (0 available); any H1f3 mutation (8 available)
H1f4^tm2Ais mutation (0 available); any H1f4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:83954 )

• no homozygotes are born

embryo

abnormal embryonic tissue morphology ( J:83954 )

• E9.5 embryos are severely retarded and abnormal

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