Phenotypes associated with this allele

• Allele Symbol: Ahr^d
• Allele Name: d variant
• Allele ID: MGI:2667196
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ahr^d/Ahr^d	AKR	MGI:3776496
hm2	Ahr^d/Ahr^d	B6.D2-Ahr^d	MGI:3776522
hm3	Ahr^d/Ahr^d	DBA/2	MGI:3776497
hm4	Ahr^d/Ahr^d	DBA/2J	MGI:3776489
hm5	Ahr^d/Ahr^d	involves: 129S1/SvImJ * C57BL/6J	MGI:3776521
ht6	Ahr^b-1/Ahr^d	involves: 129S1/SvImJ * C57BL/6J	MGI:3776520
ht7	Ahr^b-1/Ahr^d	involves: C57BL/6 * DBA/2	MGI:3776523

Genotype
MGI:3776496

hm1

• Allelic Composition: Ahr^d/Ahr^d
• Genetic Background: AKR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

decreased physiological sensitivity to xenobiotic ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

Genotype
MGI:3776522

hm2

• Allelic Composition: Ahr^d/Ahr^d
• Genetic Background: B6.D2-Ahr^d

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• unlike C57BL/6-Ahr^b-1 neonates, mice are not susceptible to lethality induced by in utero exposure to cHBB

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• unlike C57BL/6-Ahr^b-1 neonates, mice are not susceptible to lethality induced by in utero exposure to cHBB

decreased physiological sensitivity to xenobiotic ( J:113285 )

• following exposure to cHBB in utero, neonates exhibit a lesser increase in volume density of hemopoietic islands in the liver compared to in C57BL/6-Ahr^b-1 neonates

Genotype
MGI:3776497

hm3

• Allelic Composition: Ahr^d/Ahr^d
• Genetic Background: DBA/2

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

decreased physiological sensitivity to xenobiotic ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

Genotype
MGI:3776489

hm4

• Allelic Composition: Ahr^d/Ahr^d
• Genetic Background: DBA/2J

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects

decreased physiological sensitivity to xenobiotic ( J:26440 , J:132380 )

• mice are resistant to the pathological effects of DMBA including mortality, morbidity and severity of effects (J:26440)

• mice are more resistant to the teratogenic effects of TCDD than Ahr^b-1 homozygotes with only 30% of mice exhibiting altered palate development compared to 100% of Ahr^b-1 homozygotes (J:132380)

• mice from mothers treated with TCDD exhibit a similar incidence of hydronephrosis as Ahr^b-1 homozygotes but at a reduced severity (J:132380)

Genotype
MGI:3776521

hm5

• Allelic Composition: Ahr^d/Ahr^d
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

• however, maternal genotype of Ahr^d/Ahr^d improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

• however, maternal genotype of Ahr^d/Ahr^d improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype

increased physiological sensitivity to xenobiotic ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

• however, maternal genotype of Ahr^d/Ahr^d improves survival of offspring exposed to DBP in utero while maternal dietary exposure to I3C increased survival of offspring exposed to DBP in utero irregardless of offspring or dam genotype

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit an increased susceptibility to developing lymphomas

• offspring exposed to DBP in utero exhibit increased rates of lung cancer (though lower than in offspring of Ahr^d/Ahr^d dams) and liver tumors in male mice

neoplasm

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit an increased susceptibility to developing lymphomas

• offspring exposed to DBP in utero exhibit increased rates of lung cancer (though lower than in offspring of Ahr^d/Ahr^d dams) and liver tumors in male mice

Genotype
MGI:3776520

ht6

• Allelic Composition: Ahr^b-1/Ahr^d
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

increased physiological sensitivity to xenobiotic ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

• however, maternal dietary exposure to I3C increased survival and decreases incidence of lung cancer of offspring exposed to DBP in utero irregardless of offspring or dam genotype

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice

neoplasm

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice

Genotype
MGI:3776523

ht7

• Allelic Composition: Ahr^b-1/Ahr^d
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB