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Allele Symbol Allele Name Allele ID |
Aldh1a1tm1Gdu targeted mutation 1, Gregg Duester MGI:2667220 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significantly reduced ability to convert retinol to retinoic acid
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| N |
• in spite of the fact that this gene is highly expressed in the dorsal retina of the mouse, its absence has no apparent effect on retinal morphology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• block at the progression at the conversion of A spermatogonia to A1
• however, injection with retinoic acid restored spermatogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• block at the progression at the conversion of A spermatogonia to A1 following chronic treatment with tamoxifen
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• sperm depletion occurs after chronic administration of tamoxifen
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• sperm depletion occurs after chronic administration of tamoxifen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• male mice exhibit normal spermatogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
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• thickened at E14.5
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• thickened folds at E14.5
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• excessive thickening of the neural retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores neural retina thickness to nearly normal
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• absent at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores vitreous body development
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• at E14.5, a prominent retrolenticular membrane is present
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
|
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
|
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
• excessive invasion of the periocular mesenchyme into the anterior retina at E14.5
• maternal dietary retinoic acid treatment from E8.5 - E14.5 restores periocular mesenchyme growth to nearly normal
|
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• at E11.5 almost no apoptotic cells are found in the dorsal and ventral regions of the periocular mesenchyme, unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E10.5 the ventral optic vesicle has not invaginated to form a complete optic cup following maternal dietary retinoic acid treatment ending at E8.5
• however, dorsal invagination does occur
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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