mortality/aging
• homozygous mutant embryos at E7.5 and at E8.0 were morphologically abnormal and severely growth retarded
• by E9.5, homozygous mutant embryos were degenerating, and no homozygous mutant progeny were seen in heterozygote intercrosses
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embryo
• at E7.5, embryonic and extraembryonic ectoderm separated by a groove
• some mesoderm cells found between ectoderm and visceral endoderm
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• failure to produce mesendoderm
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• anteroposterior axis is not specified
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• absence of typical egg cylinder shape at E6.5
• ectoderm did not exhibit its characteristic groove and always showed an abnormally large gap
• numerous dying cells with pyknotic nuclei detected on each side of the gap and within the proamniotic cavity
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• failure to produce embryonic mesoderm
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• markedly disorganized, does not form a node and fails to produce mesendoderm and embryonic mesoderm
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• no primitive node is formed
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• no headfolds, allantois and proamniotic cavity remain undivided
• embryos with amniotic folds and with proamniotic cavity divided into 3 compartments but indications of apoptosis also appearing
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | Sotos syndrome | DOID:14748 |
OMIM:PS117550 |
J:83923 |