Phenotypes associated with this allele

• Allele Symbol: Ahr^b-1
• Allele Name: b-1 variant
• Allele ID: MGI:2667308
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ahr^b-1/Ahr^b-1	C57BL/6J	MGI:2667804
hm2	Ahr^b-1/Ahr^b-1	C58/J	MGI:3776492
hm3	Ahr^b-1/Ahr^b-1	involves: C57BL/6J * DBA/2J	MGI:2667805
ht4	Ahr^b-1/Ahr^d	involves: 129S1/SvImJ * C57BL/6J	MGI:3776520
ht5	Ahr^b-1/Ahr^d	involves: C57BL/6 * DBA/2	MGI:3776523
cn6	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Speer6-ps1^Tg(Alb-cre)21Mgn Aip^tm2.1Bra	MGI:4867849
cx7	Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra	B6.Cg-Aip^tm2.1Bra	MGI:4867848

Genotype
MGI:2667804

hm1

• Allelic Composition: Ahr^b-1/Ahr^b-1
• Genetic Background: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 , J:113285 )

• mice are susceptible to DMBA induced lethality (J:26440)

• mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahr^d allele (J:113285)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:5387 )

N • topical application of the polycyclic hydrocarbon DMBA induced hepatic aryl hydrocarbon hydroxylase activity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 , J:113285 )

• mice are susceptible to DMBA induced lethality (J:26440)

• mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahr^d allele (J:113285)

increased physiological sensitivity to xenobiotic ( J:26440 , J:113285 , J:132380 )

• mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight (J:26440)

• mice exposed to DMBA exhibit decreased lymphocyte counts, increased polymorphic cells, decreased bone marrow cell counts and ascites formation (J:26440)

• when mice are fostered by control C57BL/6 dams following in utero exposure to cHBB, 21% of neonates survive (J:113285)

• mice exhibit neonatal lethality in response to in utero exposure to cHBB and decreased thymus and spleen weights compared to untreated mice (J:113285)

• following exposure to cHBB in utero, neonates exhibit an increase in volume density of hematopoietic islands in the liver (J:113285)

• mice are susepctible to the teratogenic effects of TCDD with 100% of mice developing cleft palates and 90% of mice developing severe hydronephrosis (J:132380)

immune system

increased inflammatory response ( J:5244 , J:5387 )

• topical application of the polycyclic hydrocarbon DMBA produced skin inflammation and ulceration (J:5244)

• topical application of DMBA produced skin inflammation and ulceration (J:5387)

Genotype
MGI:3776492

hm2

• Allelic Composition: Ahr^b-1/Ahr^b-1
• Genetic Background: C58/J

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are susceptible to DMBA induced lethality

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:26440 )

• mice are susceptible to DMBA induced lethality

increased physiological sensitivity to xenobiotic ( J:26440 )

• mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight

Genotype
MGI:2667805

hm3

• Allelic Composition: Ahr^b-1/Ahr^b-1
• Genetic Background: involves: C57BL/6J * DBA/2J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:5387 )

N • Background Sensitivity: i.p. injection of the polycyclic hydrocarbon 3-methylcholanthrene induced hepatic aryl hydrocarbon hydroxylase activity unlike in strains homozygous for the unresponsive allele

immune system

abnormal immune system physiology ( J:5387 )

• i.p. injection of the polycyclic hydrocarbon 3MC produced skin inflammation and skin ulcers

Genotype
MGI:3776520

ht4

• Allelic Composition: Ahr^b-1/Ahr^d
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

increased physiological sensitivity to xenobiotic ( J:113356 )

• mice are sensitive to in utero exposure to DBP and at three months of age develop difficulty breathing, anemia, hypoxia, large thoracic masses, enlarged spleens, livers and lymph nodes, and must be euthanized

• however, maternal dietary exposure to I3C increased survival and decreases incidence of lung cancer of offspring exposed to DBP in utero irregardless of offspring or dam genotype

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice

neoplasm

increased incidence of tumors by chemical induction ( J:113356 )

• offspring exposed to DBP in utero exhibit increased rates of lung cancer and liver tumors in male mice

Genotype
MGI:3776523

ht5

• Allelic Composition: Ahr^b-1/Ahr^d
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:113285 )

• like C57BL/6-Ahr^b-1 neonates, mice exhibit neonatal lethality in response to in utero exposure to cHBB

Genotype
MGI:4867849

cn6

• Allelic Composition: Ahr^b-1/Ahr^b-1; Aip^tm2.1Bra/Aip^tm2.1Bra; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Aip^tm2.1Bra

Ahr^b-1/Ahr^b-1 Aip^tm2.1Bra/Aip^tm2.1Bra Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice are resistant to dioxin-induced hepatic damage

homeostasis/metabolism

abnormal circulating alanine transaminase level ( J:166864 )

• doxin-treated mice do not exhibit an increase in serum alanine transaminase unlike similarly treated Aip^tm2.1Bra homozygotes

decreased physiological sensitivity to xenobiotic ( J:166864 )

• doxin-treated mice do not exhibit an increase in serum alanine transferase and are resistant to induced hepatic damage unlike similarly treated Aip^tm2.1Bra homozygotes

• however, doxin-treated mice exhibit increased liver and thymus weight similar to wild-type mice

cardiovascular system

patent ductus venosus ( J:166864 )

• in 1 of 8 mice

growth/size/body

decreased body size ( J:166864 )

• at 8 weeks

cellular

patent ductus venosus ( J:166864 )

• in 1 of 8 mice

Genotype
MGI:4867848

cx7

• Allelic Composition: Ahr^b-1/Ahr^b-1; Aip^tm2.1Bra/Aip^tm2.1Bra
• Genetic Background: B6.Cg-Aip^tm2.1Bra

cardiovascular system

cardiovascular system phenotype ( J:166864 )

N • mice do not exhibit patent ductus venosus