Phenotypes associated with this allele

• Allele Symbol: Tbxa2r^tm1Sna
• Allele Name: targeted mutation 1, Shuh Narumiya
• Allele ID: MGI:2667333
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbxa2r^tm1Sna/Tbxa2r^tm1Sna	B6.Cg-Tbxa2r^tm1Sna	MGI:5517587
hm2	Tbxa2r^tm1Sna/Tbxa2r^tm1Sna	either: (involves: 129/Ola * BALB/c) or (involves: 129/Ola * C57BL/6)	MGI:2670653

Genotype
MGI:5517587

hm1

• Allelic Composition: Tbxa2r^tm1Sna/Tbxa2r^tm1Sna
• Genetic Background: B6.Cg-Tbxa2r^tm1Sna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism

edema ( J:197334 )

• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

Genotype
MGI:2670653

hm2

• Allelic Composition: Tbxa2r^tm1Sna/Tbxa2r^tm1Sna
• Genetic Background: either: (involves: 129/Ola * BALB/c) or (involves: 129/Ola * C57BL/6)

hematopoietic system

enlarged spleen ( J:84085 )

• splenomegaly seen in F2 mice on a C57BL/6 background

immune system

abnormal immune system organ morphology ( J:84085 )

enlarged spleen ( J:84085 )

• splenomegaly seen in F2 mice on a C57BL/6 background

abnormal lymph node morphology ( J:84085 )

• zonal structure of lymph nodes disrupted

• follicles with T and B cells found throughout the nodes

enlarged lymph nodes ( J:84085 )

• develops with age (at 30 weeks) in cervical lymph nodes

abnormal cervical lymph node morphology ( J:84085 )

• lymphadenopathy develops with age (seen at 30 weeks)

abnormal immune system physiology ( J:84085 )

• decreased adhesion of dendritic cells and T cells

abnormal type I hypersensitivity reaction ( J:84085 )

• enhanced contact hypersensitivity

abnormal immune serum protein physiology ( J:84085 )

• immunoglobulin production is enhanced in F2 mice on a C57BL/6 background but not after further backcrosses or on the BALB/c background

growth/size/body

enlarged spleen ( J:84085 )

• splenomegaly seen in F2 mice on a C57BL/6 background