All Phenotypes Dclre1c<tm1Fwa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclre1c^tm1Fwa/Dclre1c^tm1Fwa	involves: 129S6/SvEvTac	MGI:3843212
hm2	Dclre1c^tm1Fwa/Dclre1c^tm1Fwa	involves: 129S6/SvEvTac * C57BL/6	MGI:2667618

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:147864 )

• thymocyte number is reduced to less than 2% of control mice

arrested B cell differentiation ( J:147864 )

• B cell development is blocked at the pro-B cell stage

abnormal T cell receptor beta chain V(D)J recombination ( J:147864 )

• the D-J and D-Jbeta1 coding joints exhibit large deletions, with >400 nt deleted from some coding flanks

• in addition, several unusually long P-nucleotide additions occur

• 24% of T cells contain N nucleotide insertions at the coding joints of greater than 5 basepairs

decreased double-positive T cell number ( J:147864 )

• there are 10-fold less double-positive thymocytes than in controls

absent B cells ( J:147864 )

• B cells are absent in the bone marrow and periphery

decreased CD4-positive, alpha-beta T cell number ( J:147864 )

• CD4⁺ T cells are virtually absent

decreased CD8-positive, alpha-beta T cell number ( J:147864 )

• CD8⁺ T cells are virtually absent

spleen hypoplasia ( J:147864 )

• spleen cellularity is 20-25% of controls

cellular

increased cellular sensitivity to gamma-irradiation ( J:147864 )

• mouse embryonic fibroblasts (MEFs) are extremely sensitive to gamma irradiation with less survival occurring compared to wild-type controls

induced chromosome breakage ( J:147864 )

• MEFs have increased levels of chromosomal aberrations 24 h after 200 rads similar to levels observed in MEFs

hematopoietic system

decreased thymocyte number ( J:147864 )

• thymocyte number is reduced to less than 2% of control mice

arrested B cell differentiation ( J:147864 )

• B cell development is blocked at the pro-B cell stage

abnormal T cell receptor beta chain V(D)J recombination ( J:147864 )

• the D-J and D-Jbeta1 coding joints exhibit large deletions, with >400 nt deleted from some coding flanks

• in addition, several unusually long P-nucleotide additions occur

• 24% of T cells contain N nucleotide insertions at the coding joints of greater than 5 basepairs

decreased double-positive T cell number ( J:147864 )

• there are 10-fold less double-positive thymocytes than in controls

absent B cells ( J:147864 )

• B cells are absent in the bone marrow and periphery

decreased CD4-positive, alpha-beta T cell number ( J:147864 )

• CD4⁺ T cells are virtually absent

decreased CD8-positive, alpha-beta T cell number ( J:147864 )

• CD8⁺ T cells are virtually absent

spleen hypoplasia ( J:147864 )

• spleen cellularity is 20-25% of controls

endocrine/exocrine glands

decreased thymocyte number ( J:147864 )

• thymocyte number is reduced to less than 2% of control mice

Allelic Composition	Dclre1c^tm1Fwa/Dclre1c^tm1Fwa
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1c^tm1Fwa mutation (1 available); any Dclre1c mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to ionizing radiation ( J:80995 )

• mouse embryonic fibroblasts (MEFs) exhibit increased ionizing radiation sensitivity but normal growth

chromosomal instability ( J:80995 )

• spontaneous chromosomal instability is increased in MEFs

hematopoietic system

decreased thymocyte number ( J:80995 )

• total thymocyte numbers are reduced 50-fold

absent immature B cells ( J:80995 )

• B220+IgM+ immature B cell population is absent

arrested B cell differentiation ( J:80995 )

• B cell development is blocked at the B220+CD43+ progenitor stage when Ig rearrangements first occur

arrested T cell differentiation ( J:80995 )

• T cell development is partially blocked at the CD4-CD8- double negative progenitor stage when Tcr rearrangements first occur

immune system

decreased thymocyte number ( J:80995 )

• total thymocyte numbers are reduced 50-fold

absent immature B cells ( J:80995 )

• B220+IgM+ immature B cell population is absent

arrested B cell differentiation ( J:80995 )

• B cell development is blocked at the B220+CD43+ progenitor stage when Ig rearrangements first occur

arrested T cell differentiation ( J:80995 )

• T cell development is partially blocked at the CD4-CD8- double negative progenitor stage when Tcr rearrangements first occur

endocrine/exocrine glands

decreased thymocyte number ( J:80995 )

• total thymocyte numbers are reduced 50-fold

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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