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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grik5tm1Cont
targeted mutation 1, Anis Contractor
MGI:2668206
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grik5tm1Cont/Grik5tm1Cont 129S/SvEv-Grik5tm1Cont MGI:2668208
cx2
 		Grik4tm1.1Sfh/Grik4tm1.1Sfh
Grik5tm1Cont/Grik5tm1Cont 		involves: 129S/SvEv * 129S4/SvJae MGI:4413560


Genotype
MGI:2668208
hm1
Allelic
Composition		 Grik5tm1Cont/Grik5tm1Cont
Genetic
Background		 129S/SvEv-Grik5tm1Cont
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik5tm1Cont mutation (0 available); any Grik5 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:81742 )
• heterosynaptic kainite receptor-mediated facilitation resulting from the spillover of glutamate from CA3 collateral synapses is absent
abnormal excitatory postsynaptic currents ( J:81742 )
• facilitation of mossy-fiber EPSCs by low kainate concentrations is absent
short excitatory postsynaptic current decay time ( J:81742 )
• the half-decay of the postsynaptic kainate-mediated EPSC is shorter




Genotype
MGI:4413560
cx2
Allelic
Composition		 Grik4tm1.1Sfh/Grik4tm1.1Sfh
Grik5tm1Cont/Grik5tm1Cont
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grik4tm1.1Sfh mutation (0 available); any Grik4 mutation (48 available)
Grik5tm1Cont mutation (0 available); any Grik5 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:155003 )
• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice
• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal
• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice
• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice
decreased paired-pulse facilitation ( J:155003 )
• at the shortest interstimulus interval, paired-pulse facilitation is impaired compared to in similarly treated wild-type mice
• however, frequency facilitation is intact

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:155003 )
• kainic acid fails to induce increases in excitatory postsynaptic current (EPSC) amplitudes unlike in similarly treated wild-type mice
• however, mice respond normally to high concentrations of kainic acid and kainate receptor-mediated inhibition of slow afterhyperpolarization current is normal
• following application with GYKI 53655, no cells exhibit GYKI-resistant EPSC unlike in similarly treated wild-type mice
• following application with GYKI 53655 and short trains of high-frequency stimulation, no GYKI-resistant EPSC is detected unlike in similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory