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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gria3tm1Zpj
targeted mutation 1, Zhengping Jia
MGI:2668336
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Gria2tm1Rod/Gria2tm1Rod
Gria3tm1Zpj/Y 		involves: 129/Sv * C57BL/6 MGI:2674947
ot2
 		Gria3tm1Zpj/Y involves: 129/Sv * C57BL/6 MGI:2674946


Genotype
MGI:2674947
cx1
Allelic
Composition		 Gria2tm1Rod/Gria2tm1Rod
Gria3tm1Zpj/Y
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm1Rod mutation (2 available); any Gria2 mutation (79 available)
Gria3tm1Zpj mutation (0 available); any Gria3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:84336 )
• normal at birth
• increased mortality at 2 to 4 weeks of age
• to about 20-30%
• gradual increase of global abnormalities

behavior/neurological
tremors ( J:84336 )
• severe tremors associated with movements

nervous system
nervous system phenotype ( J:84336 )
N
• no gross anatomic abnormalities seen in the CNS
• synaptic structures in the CA1 region appear normal
abnormal synaptic plasticity ( J:84336 )
• synaptic plasticity was greater
abnormal excitatory postsynaptic potential ( J:84336 )
• field excitatory postsynaptic potential was reduced to 10-20% of wild-type and was significantly lower than in Gria2 mutant homozygotes
enhanced long-term potentiation ( J:84336 )
• in the CA1 region
abnormal long-term depression ( J:84336 )
• in the CA1 region LTD is enhanced
• limited effect of D15 peptide in blocking LTD

growth/size/body
decreased body size ( J:84336 )




Genotype
MGI:2674946
ot2
Allelic
Composition		 Gria3tm1Zpj/Y
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria3tm1Zpj mutation (0 available); any Gria3 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:84336 )
• male hemizygous mutants breed poorly

nervous system
abnormal long-term potentiation ( J:84336 )
• in the CA1 region long-term potentiation induced by high frequency stimulation is significantly enhanced and saturation level induced by multiple high frequency stimulation trains is also enhanced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory