Phenotypes associated with this allele

• Allele Symbol: Prdx6^tm1Pgn
• Allele Name: targeted mutation 1, Beverly Paigen
• Allele ID: MGI:2668338
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdx6^tm1Pgn/Prdx6^tm1Pgn	either: 129/Sv or (involves: 129/Sv * C57BL/6)	MGI:2674958

Genotype
MGI:2674958

hm1

• Allelic Composition: Prdx6^tm1Pgn/Prdx6^tm1Pgn
• Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood circulation ( J:84376 )

• in mice injected intraperitoneally with paraquat to induce oxidative stress

lung hemorrhage ( J:84376 )

• severe hemorrhaging seen on the surface and interior of lungs both grossly and microscopically

pulmonary alveolar hemorrhage ( J:84376 )

kidney hemorrhage ( J:84376 )

• severe hemorrhaging seen in the kidneys microscopically

liver hemorrhage ( J:84376 )

• severe hemorrhaging seen on the surface and interior of the liver both grossly and microscopically

cellular

oxidative stress ( J:84376 )

• in mice injected intraperitoneally with paraquat to induce oxidative stress

• increased susceptibility to oxidative stress

• 75% death rate in 3-4 days when on a B6 and 129 background

• 50% death rate when on a 129 background

renal/urinary system

kidney hemorrhage ( J:84376 )

• severe hemorrhaging seen in the kidneys microscopically

abnormal kidney morphology ( J:84376 )

• in mice injected intraperitoneally with paraquat to induce oxidative stress

cortical renal glomerulopathies ( J:84376 )

• swollen glomeruli

• capillaries of glomeruli congested

abnormal renal tubule morphology ( J:84376 )

• contain protein casts indicative of increased capillary permeability

abnormal renal tubule epithelium morphology ( J:84376 )

• epithelial cells of renal tubules degenerate

renal cast ( J:84376 )

• renal tubules contain protein casts indicative of increased capillary permeability

respiratory system

lung hemorrhage ( J:84376 )

• severe hemorrhaging seen on the surface and interior of lungs both grossly and microscopically

pulmonary alveolar hemorrhage ( J:84376 )

abnormal respiratory system morphology ( J:84376 )

• in mice injected intraperitoneally with paraquat to induce oxidative stress

abnormal pulmonary alveolar duct morphology ( J:84376 )

• collapsed alveolar ducts

abnormal pulmonary alveolus morphology ( J:84376 )

• collapsed alveoli

pulmonary alveolar edema ( J:84376 )

pulmonary necrosis ( J:84376 )

• diffuse pulmonary necrosis

pulmonary epithelial necrosis ( J:84376 )

• lung epithelial necrosis

homeostasis/metabolism

abnormal blood coagulation ( J:84376 )

• in mice injected intraperitoneally with paraquat to induce oxidative stress

abnormal venous thrombosis ( J:84376 )

• thromboses in bronchial veins

abnormal kidney venous thrombosis ( J:84376 )

• thrombi common in veins of kidney

pulmonary alveolar edema ( J:84376 )

liver/biliary system

liver hemorrhage ( J:84376 )

• severe hemorrhaging seen on the surface and interior of the liver both grossly and microscopically