normal phenotype
• no obvious behavioral abnormalities
• no demyelination seen in spinal cords of animals between 12 and 26 weeks of age
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Allele Symbol Allele Name Allele ID |
Gjc2tm1Paul targeted mutation 1, David L Paul MGI:2668351 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no obvious behavioral abnormalities
• no demyelination seen in spinal cords of animals between 12 and 26 weeks of age
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• animals die around 6 weeks of age
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• coarse action tremor developed during the third week of age
• tremor was accentuated with movement
• condition worsened with time
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• develop by week 4-5
• characterized by limb extension and loss of consciousness
• frequency and severity increased until death around week 6
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• delayed myelination in optic nerve
• no myelin sheath at day 7
• myelination abnormalities appear as myelination increased
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• develop by week 4-5
• characterized by limb extension and loss of consciousness
• frequency and severity increased until death around week 6
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• delayed myelination in optic nerve
• no myelin sheath at day 7
• myelination abnormalities appear as myelination increased
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• thin myelin sheaths
• enlarged extra cellular spaces under sheaths
• abnormal oligodendrocytes
• empty myelin sheaths
• variability from one tract to another in conditions observed
• apoptotic cells in affected tracts
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• demyelinated axons
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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