Phenotypes associated with this allele

• Allele Symbol: Hip1^tm1Hay
• Allele Name: targeted mutation 1, Michael Hayden
• Allele ID: MGI:2668380
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hip1^tm1Hay/Hip1^tm1Hay	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2668381

Genotype
MGI:2668381

hm1

• Allelic Composition: Hip1^tm1Hay/Hip1^tm1Hay
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84278 )

• premature death several months after development of the thoracolumbar kyphosis

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:84278 )

• range of motion in both fore and hindlimbs is limited

tremors ( J:84278 )

• evident at 3 monthes of age

• tremor involving primarily the trunk musculature, occurring more than 10 times a min and lasting less than 5 seconds

abnormal gait ( J:84278 )

• abnormal gait characterized by a reduction in average stride length and wide splaying of the hindlegs resulting in an increase in stride width

• secondary to rigid thoracolumbar kyphosis

short stride length ( J:84278 )

decreased locomotor activity ( J:84278 )

growth/size/body

decreased body weight ( J:84278 )

• failure to thrive

postnatal growth retardation ( J:84278 )

• from about 12 weeks of age, mutants show growth retardation

skeleton

kyphosis ( J:84278 )

• from about 12 weeks of age, mutants develop a progressive rigid thoracolumbar kyphosis such that by 9-10 months of age and 1 year of age, 50% and 85% of mutants are affected, respectively

• females are affected earlier than males

muscle

abnormal muscle morphology ( J:84278 )

• reduction in muscle bulk