Phenotypes associated with this allele

• Allele Symbol: Rock2^tm1Sna
• Allele Name: targeted mutation 1, Shuh Narumiya
• Allele ID: MGI:2668391
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rock2^tm1Sna/Rock2^tm1Sna	involves: 129X1/SvJ * C57BL/6	MGI:2675311

Genotype
MGI:2675311

hm1

• Allelic Composition: Rock2^tm1Sna/Rock2^tm1Sna
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84386 )

• deaths from 3-4 weeks to 11 months

prenatal lethality, incomplete penetrance ( J:84386 )

• by E18.5 only 7.7% of embryos are homozygous for this allele

• only 5.3% (n=8) of live births are homozygotes

cardiovascular system

hemorrhage ( J:84386 )

• hemorrhage in hind limb bud as early as E12.5

• dilation and bursting of small capillaries at tip of hind limb

• results in swelling of limbs

• bleeding resolves in 3-4 days of birth but often results in foot deformities

• tail tip hemorrhage more rarely

embryo

abnormal extraembryonic tissue morphology ( J:84386 )

• actin fiber structure in trophoblast was normal

abnormal placenta morphology ( J:84386 )

• recovery from growth deficit at birth implies defect in interaction of embryo and placenta

• placentas normal to E11.5

• after E12.5 large blood clots visible

• clots in labyrinth layer involve maternal circulation

• increasing clot size and number

growth/size/body

decreased body size ( J:84386 )

• body size was reduced in surviving mice

• growth deficit was recovered after birth

• subsequent development was normal