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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad2tm2Rob
targeted mutation 2, Elizabeth J Robertson
MGI:2668393
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad2tm2Rob/Smad2tm2Rob involves: 129S/SvEv * C57BL/6 MGI:3689501
cn2
 		Smad2tm1Rob/Smad2tm2Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S/SvEv * C57BL/6 * CBA * CD-1 MGI:2668417
cn3
 		Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1 MGI:3689505


Genotype
MGI:3689501
hm1
Allelic
Composition		 Smad2tm2Rob/Smad2tm2Rob
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2tm2Rob mutation (1 available); any Smad2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:84300 )
• mice are viable and fertile




Genotype
MGI:2668417
cn2
Allelic
Composition		 Smad2tm1Rob/Smad2tm2Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Smad2tm1Rob mutation (0 available); any Smad2 mutation (52 available)
Smad2tm2Rob mutation (1 available); any Smad2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal rostral-caudal axis patterning ( J:84300 )
• at E8.5, rostral neurectoderm tissue is reduced in size
• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei
abnormal anterior definitive endoderm morphology ( J:84300 )
• there are reduced numbers of anterior definitive endoderm (ADE) cells

digestive/alimentary system
truncated foregut ( J:84300 )
• gut tube forms but is poorly elaborated in anterior region; instead of extending to level of Rathke's pouch like wild-type, no gut tissue is evident at this level in mutants and is absent anterior to level of heart

cardiovascular system
abnormal heart looping ( J:84300 )
• heart tube is abnormally looped
pericardial edema ( J:84300 )
• pericardium is often edematous
enlarged pericardium ( J:84300 )
• pericardium is often enlarged

nervous system
absent midbrain ( J:84300 )
• embryos lack all prospective midbrain tissue
absent forebrain ( J:84300 )
• embryos lack all prospective forebrain tissue

homeostasis/metabolism
pericardial edema ( J:84300 )
• pericardium is often edematous




Genotype
MGI:3689505
cn3
Allelic
Composition		 Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Smad2tm1Rob mutation (0 available); any Smad2 mutation (52 available)
Smad2tm2Rob mutation (1 available); any Smad2 mutation (52 available)
Smad3tm1Xfw mutation (0 available); any Smad3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
rostral body truncation ( J:84300 )
• embryos develop severe anterior truncations at E8.5
fused somites ( J:84300 )
• somites are fused across the midline at E8.5

digestive/alimentary system
absent foregut ( J:84300 )
• anterior gut is absent

cardiovascular system
abnormal heart development ( J:84300 )
• embryos develop heart malformations at E8.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory