All Phenotypes Bard1<tm1Thl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bard1^tm1Thl/Bard1^tm1Thl	involves: 129S1/Sv	MGI:2675365
cn2	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA	MGI:3805023
cn3	Bard1^tm1Thl/Bard1^tm2Thl Wap^tm1(cre)Arge/0	involves: 129S1/Sv * C57BL/6J	MGI:3805024
cx4	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge	involves: 129S/SvEv * 129S1/Sv	MGI:2675414
cx5	Bard1^tm1Thl/Bard1^tm1Thl Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129S2/SvPas	MGI:2675374

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:84329 )

• by E8.5 homozygous embryos are undergoing resorption

• mutant embryos do not develop past the egg cylinder stage and die between E7.5 and E8.5

embryo

abnormal developmental patterning ( J:84329 )

abnormal gastrulation ( J:84329 )

• embryos had reached 2 layer egg cylinder stage at E6.5

• E6.5 embryos were half normal size, most oviouly in embryonic structures

• never developed past egg cylinder stage

• hypoproliferation at E6.5, apoptosis levels normal

abnormal embryonic tissue morphology ( J:84329 )

inner cell mass degeneration ( J:84329 )

• after 2 days of culture ICM from embryos collected at E3.5 started to degenerate

Allelic Composition	Bard1^tm1Thl/Bard1^tm2Thl Tg(Hsp70-1-cre)1Arge/0
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Bard1^tm2Thl mutation (0 available); any Bard1 mutation (55 available)
Tg(Hsp70-1-cre)1Arge mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:134977 )

• lethality occurs early in embryonic development

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

integument

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:134977 )

• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 465 days

• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive

• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate

• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes

• neoplasms often invade in a broad front and push towards the underlying pectoral muscle

• a small minority of tumors have sqaumous characteristics

• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:134977

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl Brca1^tm1Arge/Brca1^tm1Arge
Genetic Background	involves: 129S/SvEv * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Brca1^tm1Arge mutation (0 available); any Brca1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

embryo

abnormal developmental patterning ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

abnormal embryonic tissue morphology ( J:84329 )

• authors state that this phenotype is identical to homozygous Bard1^tm1Thl

Allelic Composition	Bard1^tm1Thl/Bard1^tm1Thl Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bard1^tm1Thl mutation (0 available); any Bard1 mutation (55 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84329 )

• survived through E9.5

cellular

chromosome breakage ( J:84329 )

• 44% of mitotic spreads showed abnormal chromosome number, usually reduced

embryo

decreased embryo size ( J:84329 )

• developmentally retarded by E9.5

open neural tube ( J:84329 )

• seen at E9.5

growth/size/body

decreased embryo size ( J:84329 )

• developmentally retarded by E9.5

nervous system

open neural tube ( J:84329 )

• seen at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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