All Phenotypes Smad2<tm2.1Rob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smad2^tm2.1Rob
targeted mutation 2.1, Elizabeth J Robertson
MGI:2668416

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^tm2.1Rob/Smad2^tm2.1Rob	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1	MGI:3689502
ht2	Smad2^tm1Rob/Smad2^tm2.1Rob	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1	MGI:3689503

Allelic Composition	Smad2^tm2.1Rob/Smad2^tm2.1Rob
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm2.1Rob mutation (0 available); any Smad2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:84300 )

embryo

abnormal rostral-caudal axis patterning ( J:84300 )

abnormal embryonic tissue morphology ( J:84300 )

• at E9.5, embryo is composed of only extraembryonic tissues, phenocopying Smad2^tm1Rob homozygotes

Allelic Composition	Smad2^tm1Rob/Smad2^tm2.1Rob
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CD-1