About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nodaltm4Rob
targeted mutation 4, Elizabeth J Robertson
MGI:2668418
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nodaltm4Rob/Nodaltm4Rob involves: 129/Sv * 129S/SvEv * C57BL/6 MGI:3689506
ht2
NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob involves: 129S/SvEv * C57BL/6 MGI:2668420
cx3
Eomestm1.1Rob/Eomes+
Nodaltm4Rob/Nodaltm4Rob
involves: 129S/SvEv * C57BL/6 * CBA MGI:3775739


Genotype
MGI:3689506
hm1
Allelic
Composition
Nodaltm4Rob/Nodaltm4Rob
Genetic
Background
involves: 129/Sv * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodaltm4Rob mutation (0 available); any Nodal mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die late in gestation or at birth due to spectrum of complex defects
• only 50% of homozygotes survive to term; remainder die late in gestation

cardiovascular system
• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including heart abnormalities

craniofacial
• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including craniofacial defects




Genotype
MGI:2668420
ht2
Allelic
Composition
NodalTgR(MPSVNeo)413.dRob/Nodaltm4Rob
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
NodalTgR(MPSVNeo)413.dRob mutation (0 available); any Nodal mutation (42 available)
Nodaltm4Rob mutation (0 available); any Nodal mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos develop severe anterior truncations at E8.5

embryo
• embryos develop severe anterior truncations at E8.5
• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei

cardiovascular system
• heart tube is abnormally looped
• pericardium is often edematous
• pericardium is often enlarged

digestive/alimentary system
• gut tube forms but is poorly elaborated in anterior region; instead of extending to level of Rathke's pouch like wild-type, no gut tissue is evident at this level in mutants and is absent anterior to level of heart

homeostasis/metabolism
• pericardium is often edematous

nervous system
• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei
• midbrain regions are not specified
• forebrain regions are not specified
• the anterior neurectoderm fails to proliferate




Genotype
MGI:3775739
cx3
Allelic
Composition
Eomestm1.1Rob/Eomes+
Nodaltm4Rob/Nodaltm4Rob
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Rob mutation (0 available); any Eomes mutation (44 available)
Nodaltm4Rob mutation (0 available); any Nodal mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• normal Mendelian numbers are recovered during embryogenesis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory