All Phenotypes Nodal<tm4Rob> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nodal^tm4Rob/Nodal^tm4Rob	involves: 129/Sv * 129S/SvEv * C57BL/6	MGI:3689506
ht2	Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm4Rob	involves: 129S/SvEv * C57BL/6	MGI:2668420
cx3	Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775739

Allelic Composition	Nodal^tm4Rob/Nodal^tm4Rob
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nodal^tm4Rob mutation (0 available); any Nodal mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:84300 )

• embryos die late in gestation or at birth due to spectrum of complex defects

prenatal lethality, incomplete penetrance ( J:84300 )

• only 50% of homozygotes survive to term; remainder die late in gestation

cardiovascular system

abnormal heart development ( J:84300 )

• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including heart abnormalities

craniofacial

abnormal craniofacial development ( J:84300 )

• ~50% of homozygotes die late in gestation or at birth from spectrum of defects including craniofacial defects

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:84300 )

• embryos develop severe anterior truncations at E8.5

embryo

rostral body truncation ( J:84300 )

• embryos develop severe anterior truncations at E8.5

abnormal embryonic neuroepithelium morphology ( J:84300 )

• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei

cardiovascular system

abnormal heart looping ( J:84300 )

• heart tube is abnormally looped

pericardial edema ( J:84300 )

• pericardium is often edematous

enlarged pericardium ( J:84300 )

• pericardium is often enlarged

digestive/alimentary system

abnormal foregut morphology ( J:84300 )

• gut tube forms but is poorly elaborated in anterior region; instead of extending to level of Rathke's pouch like wild-type, no gut tissue is evident at this level in mutants and is absent anterior to level of heart

homeostasis/metabolism

pericardial edema ( J:84300 )

• pericardium is often edematous

nervous system

abnormal embryonic neuroepithelium morphology ( J:84300 )

• at E9.5, anterior neurectoderm fails to proliferate and is filled with pyknotic nuclei

absent midbrain ( J:84300 )

• midbrain regions are not specified

absent forebrain ( J:84300 )

• forebrain regions are not specified

decreased embryonic neuroepithelial cell proliferation ( J:84300 )

• the anterior neurectoderm fails to proliferate

Allelic Composition	Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (44 available)
Nodal^tm4Rob mutation (0 available); any Nodal mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131055 )

• normal Mendelian numbers are recovered during embryogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24