Phenotypes associated with this allele

• Allele Symbol: Grb10^{Gt(Betageo)1Ward}
• Allele Name: gene trap 1, Andrew Ward
• Allele ID: MGI:2668436
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grb10^Gt(Betageo)1Ward/Grb10^Gt(Betageo)1Ward	involves: C57BL/6 * CBA	MGI:2668440
ht2	Grb10^Gt(Betageo)1Ward/Grb10^+	involves: C57BL/6 * CBA	MGI:2668444

Genotype
MGI:2668440

hm1

• Allelic Composition: Grb10^{Gt(Betageo)1Ward}/Grb10^{Gt(Betageo)1Ward}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

enlarged placenta ( J:84425 )

• the size of the placenta was also increased ~30% relative to wild-type

growth/size/body

increased birth body size ( J:84425 )

• neonates are ~30% larger than wild-type

increased fetal size ( J:84425 )

• embryonic overgrowth resulting in neonates that are ~30% larger than wild-type

enlarged liver ( J:84425 )

• disproportionate overgrowth of the liver

liver/biliary system

enlarged liver ( J:84425 )

• disproportionate overgrowth of the liver

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Silver-Russell syndrome	DOID:14681	OMIM:180860	J:84425

Genotype
MGI:2668444

ht2

• Allelic Composition: Grb10^{Gt(Betageo)1Ward}/Grb10⁺
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

perinatal lethality, incomplete penetrance ( J:84425 )

• approximately 12% of mice with a maternally inherited allele die shortly after birth

cellular

paternal imprinting ( J:84425 )

• only heterozygotes inheriting the allele from the mother display a phenotype

embryo

enlarged placenta ( J:84425 )

• the size of the placenta is increased ~30% relative to wild-type

growth/size/body

increased birth body size ( J:84425 )

• neonates are ~30% larger than wild-type

increased fetal size ( J:84425 )

• embryonic overgrowth resulting in neonates that are ~30% larger than wild-type

enlarged liver ( J:84425 )

• disproportionate overgrowth of the liver

liver/biliary system

enlarged liver ( J:84425 )

• disproportionate overgrowth of the liver

increased liver glycogen level ( J:84425 )

• hepatocytes have a very high glycogen content

homeostasis/metabolism

increased liver glycogen level ( J:84425 )

• hepatocytes have a very high glycogen content

respiratory system

abnormal pulmonary alveolus morphology ( J:84425 )

• mice that die shortly after birth exhibit blood-filled alveoli

abnormal trachea morphology ( J:84425 )

• mice that die shortly after birth exhibit a blood-filled trachea

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Silver-Russell syndrome	DOID:14681	OMIM:180860	J:84425