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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mt1tm1Rch
targeted mutation 1, Anna E Michalska
MGI:2668454
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Mt1tm1Rch/Mt1tm1Rch
Mt2tm1Rch/Mt2tm1Rch
involves: 129P2/OlaHsd * C57BL/6J MGI:2675388


Genotype
MGI:2675388
cx1
Allelic
Composition
Mt1tm1Rch/Mt1tm1Rch
Mt2tm1Rch/Mt2tm1Rch
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mt1tm1Rch mutation (2 available); any Mt1 mutation (49 available)
Mt2tm1Rch mutation (0 available); any Mt2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice

homeostasis/metabolism
• in acetaminophen-treated mice
• increased cadmium sensitivity
• take up a hunched back posture, ruffed coat and display general lethargy
• acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice
• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice
• mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice
• acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice
• however, acetaminophen metabolism is normal
• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells
• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger

liver/biliary system
• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells
• in acetaminophen-treated mice

neoplasm
• 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks)
• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory