About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mt1tm1Rch
targeted mutation 1, Anna E Michalska
MGI:2668454
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Mt1tm1Rch/Mt1tm1Rch
Mt2tm1Rch/Mt2tm1Rch
involves: 129P2/OlaHsd * C57BL/6J MGI:2675388


Genotype
MGI:2675388
cx1
Allelic
Composition
Mt1tm1Rch/Mt1tm1Rch
Mt2tm1Rch/Mt2tm1Rch
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mt1tm1Rch mutation (2 available); any Mt1 mutation (49 available)
Mt2tm1Rch mutation (0 available); any Mt2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice

homeostasis/metabolism
• in acetaminophen-treated mice
• increased cadmium sensitivity
• take up a hunched back posture, ruffed coat and display general lethargy
• acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice
• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice
• mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice
• acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice
• however, acetaminophen metabolism is normal
• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells
• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger

liver/biliary system
• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells
• in acetaminophen-treated mice

neoplasm
• 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks)
• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory