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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad23atm1Jhjh
targeted mutation 1, Jan H J Hoeijmaker
MGI:2668469
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad23atm1Jhjh/Rad23atm1Jhjh involves: 129P2/OlaHsd * C57BL/6 MGI:2672043
cx2
 		Rad23atm1Jhjh/Rad23atm1Jhjh
Rad23btm1Gvh/Rad23b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:2672047
cx3
 		Rad23atm1Jhjh/Rad23a+
Rad23btm1Gvh/Rad23btm1Gvh 		involves: 129P2/OlaHsd * C57BL/6 MGI:2672056
cx4
 		Rad23atm1Jhjh/Rad23atm1Jhjh
Rad23btm1Gvh/Rad23btm1Gvh 		involves: 129P2/OlaHsd * C57BL/6 MGI:2672067


Genotype
MGI:2672043
hm1
Allelic
Composition		 Rad23atm1Jhjh/Rad23atm1Jhjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation (0 available); any Rad23a mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2672047
cx2
Allelic
Composition		 Rad23atm1Jhjh/Rad23atm1Jhjh
Rad23btm1Gvh/Rad23b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation (0 available); any Rad23a mutation (12 available)
Rad23btm1Gvh mutation (0 available); any Rad23b mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2672056
cx3
Allelic
Composition		 Rad23atm1Jhjh/Rad23a+
Rad23btm1Gvh/Rad23btm1Gvh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation (0 available); any Rad23a mutation (12 available)
Rad23btm1Gvh mutation (0 available); any Rad23b mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:84299 )
• however, cells are capable of nucleotide excision repair
• embryos survive at least through E13.5 when mouse embryo fibroblasts were isolated




Genotype
MGI:2672067
cx4
Allelic
Composition		 Rad23atm1Jhjh/Rad23atm1Jhjh
Rad23btm1Gvh/Rad23btm1Gvh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad23atm1Jhjh mutation (0 available); any Rad23a mutation (12 available)
Rad23btm1Gvh mutation (0 available); any Rad23b mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:84299 )
• embryos die sometime between E8.5 and E10.5

cellular
abnormal DNA repair ( J:84299 )
• embryos are deficient in nucleotide excision repair

homeostasis/metabolism
abnormal DNA repair ( J:84299 )
• embryos are deficient in nucleotide excision repair




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory