Phenotypes associated with this allele

• Allele Symbol: Runx1^tm2Spe
• Allele Name: targeted mutation 2, Nancy A Speck
• Allele ID: MGI:2668479
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Runx1^tm1Spe/Runx1^tm2Spe	either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)	MGI:2671954
ht2	Runx1^tm1Yg/Runx1^tm2Spe	either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)	MGI:3760802
cn3	Runx1^tm2Spe/Runx1^tm3Spe Tg(KRT5-cre)5132Jlj/0	either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)	MGI:3709862

Genotype
MGI:2671954

ht1

• Allelic Composition: Runx1^tm1Spe/Runx1^tm2Spe
• Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal embryonic hematopoiesis ( J:56184 )

• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries

• no fetal liver hematopoiesis

• no yolk sac hematopoiesis

embryo

abnormal embryonic hematopoiesis ( J:56184 )

• absence of hematopoietic colonies in fetal livers, vitelline and umbilical arteries

• no fetal liver hematopoiesis

• no yolk sac hematopoiesis

Genotype
MGI:3760802

ht2

• Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe
• Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:125830 )

• mice die between E11.5 and E12.5 of hemorrhages in the central nervous system

cardiovascular system

internal hemorrhage ( J:125830 )

• mice die of hemorrhages in the central nervous system extensively in the fourth ventricle, ventral metencephalon and spinal cord

intracranial hemorrhage ( J:125830 )

spinal hemorrhage ( J:125830 )

nervous system

intracranial hemorrhage ( J:125830 )

spinal hemorrhage ( J:125830 )

Genotype
MGI:3709862

cn3

• Allelic Composition: Runx1^tm2Spe/Runx1^tm3Spe; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)

integument

increased curvature of auchene hairs ( J:116050 )

• majority of auchene hair type are altered in shape, many with more pronounced bends

abnormal coat appearance ( J:116050 )

• adult coat appears less dense and ruffled than controls

abnormal zigzag hair morphology ( J:116050 )

• about 90% of zigzag (ZZ) type hair show much less pronounced bends in 6-month old adults

• hair forms exhibit a variable number of bends compared to the three bend in control hairs; many do not have alternating bend patterns of control hairs, but have 2 bends in same direction

decreased curvature of zigzag hairs ( J:116050 )

• ~90% of zigzag (ZZ) type hair shows much less pronounced bends in 6-month old adults