About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm2Detl
targeted mutation 2, Peter J Detloff
MGI:2668517
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hprt1tm2Detl/Hprt1tm2Detl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2668523
ot2
 		Hprt1tm2Detl/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2668531


Genotype
MGI:2668523
hm1
Allelic
Composition		 Hprt1tm2Detl/Hprt1tm2Detl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2Detl mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84451 )
• median age of death is 10.5 months

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:84451 )
• mutants lose the ability to escape a tail suspension by climbing onto the observer's hand
decreased locomotor activity ( J:84451 )
• reduced nocturnal activity; mutants roam only 25% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice
• inactivity in open cage
• age of onset was approximately 1 month earlier than observed in either Hprttm4Detl or Hprttm6Detl mutant mice
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age

nervous system
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age
neuronal intranuclear inclusions ( J:84451 )
• neuronal intranuclear inclusions evident by 8-9 months of age; inclusions are larger than in Hprttm4Detl or Hprttm6Detl




Genotype
MGI:2668531
ot2
Allelic
Composition		 Hprt1tm2Detl/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2Detl mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84451 )
• median age of death is 10.5 months

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:84451 )
• mutants lose the ability to escape a tail suspension by climbing onto the observer's hand
decreased locomotor activity ( J:84451 )
• reduced nocturnal activity; mutants roam only 25% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice
• inactivity in open cage
• age of onset is approximately 1 month earlier than observed in either Hprttm4Detl or Hprttm6Detl mutant mice
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age

nervous system
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age
neuronal intranuclear inclusions ( J:84451 )
• neuronal intranuclear inclusions evident by 8-9 months of age; inclusions are larger than in Hprttm4Detl or Hprttm6Detl mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory