Phenotypes associated with this allele

• Allele Symbol: Hprt1^tm4Detl
• Allele Name: targeted mutation 4, Peter J Detloff
• Allele ID: MGI:2668519
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hprt1^tm4Detl/Hprt1^tm4Detl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2668525
ot2	Hprt1^tm4Detl/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2668533

Genotype
MGI:2668525

hm1

• Allelic Composition: Hprt1^tm4Detl/Hprt1^tm4Detl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84451 )

♀ • median age of death is 12 months

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:84451 )

♀ • mice exhibit better performance in the ability to escape a tail suspension than Hprt^tm2Detl or Hprt^tm6Detl mutant

abnormal reflex ( J:84451 )

♀ • mutants exhibit a delay in onset of clasping behavior

decreased locomotor activity ( J:84451 )

♀ • reduced nocturnal activity; mutants roam only 37% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice

♀ • inactivity in open cage

♀ • age of onset is approximately 1 month later than observed in Hprt^tm2Detl mutant mice

seizures ( J:84451 )

♀ • 4 of 15 mutants have seizures at 7-9 months of age; fewer seizures observed than in either Hprt^tm2Detl or Hprt^tm6Detl mutant mice

nervous system

seizures ( J:84451 )

♀ • 4 of 15 mutants have seizures at 7-9 months of age; fewer seizures observed than in either Hprt^tm2Detl or Hprt^tm6Detl mutant mice

neuronal intranuclear inclusions ( J:84451 )

♀ • neuronal intranuclear inclusions evident by 8-9 months of age

Genotype
MGI:2668533

ot2

• Allelic Composition: Hprt1^tm4Detl/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

premature death ( J:84451 )

♂ • median age of death is 12 months

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:84451 )

♂ • mice exhibit better performance in the ability to escape a tail suspension than Hprt^tm2Detl or Hprt^tm6Detl mutants

abnormal reflex ( J:84451 )

♂ • mutants exhibit a delay in onset of clasping behavior

decreased locomotor activity ( J:84451 )

♂ • reduced nocturnal activity; mutants roam only 37% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice

♂ • inactivity in open cage

♂ • age of onset was approximately 1 month later than observed in Hprt^tm2Detl mutant mice

seizures ( J:84451 )

♂ • 4 of 15 mutants have seizures at 7-9 months of age; fewer seizures observed than in either Hprt^tm2Detl or Hprt^tm6Detl mutant mice

nervous system

seizures ( J:84451 )

♂ • 4 of 15 mutants have seizures at 7-9 months of age; fewer seizures observed than in either Hprt^tm2Detl or Hprt^tm6Detl mutant mice

neuronal intranuclear inclusions ( J:84451 )

♂ • neuronal intranuclear inclusions evident by 8-9 months of age