Analysis Tools|
Allele Symbol Allele Name Allele ID |
Prkg1tm2Naw targeted mutation 2, Hermann Nawrath MGI:2668652 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cGMP analogues reduce the force of contraction in cardiac muscle from adult controls but not from adult mutants
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• cGMP analogues reduce the force of contraction in cardiac muscle from adult controls but not from adult mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• long term depression in the cerebellum is suppressed
• motor coordination as determined by footprint, runway, and rotarod tests was normal
• less vestibulo-occular reflex adaptation than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant GI motor dysfunction is observed with tamoxifen treatment
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• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice
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• GI transit time is increased by about 2 hours in treated mutants
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• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice have a normal life expectancy
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| N |
• adult conditional mutant mice display no significant differences in baseline synaptic transmission relative to control littermates
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• adult (12-14 weeks of age) but not juvenile (3-4 weeks of age) conditional mutant mice display reduced hippocampal LTP after repetitive episodes of theta burst stimulation (TBS)
• the difference in LTP between adult conditional and control mice is abolished by anisomycin (a protein synthesis inhibitor), suggesting a defect in late-phase LTP
• however, both juvenile and adult conditional mutant mice show a normal LTP in response to a single episode of tetanic stimulation, regardless of whether a weak TBS or a strong tetanic stimulus is used
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| N |
• despite a deficit in late-phase LTP, adult conditional mutant mice exhibit normal performance in hippocampus-dependent behavioral tests, i.e., contextual fear conditioning and spatial learning, with no significant differences in the freezing response to the conditioning context, in acquisition of a spatial searching strategy, or in storage and retrieval of spatial memory relative to control mice
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| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice display no detectable cardiovascular abnormalities
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| N |
• unlike Prkg1tm1Hfm homozygotes, conditional mutant mice display no detectable gastrointestinal abnormalities
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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