All Phenotypes Neurod6<tm1(cre)Kan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Neurod6^tm1(cre)Kan
targeted mutation 1, Klaus-Armin Nave
MGI:2668659

Summary

22 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cnr1^tm2Ltz/Cnr1^tm2.1Ltz Neurod6^tm1(cre)Kan/Neurod6⁺	B6.Cg-Cnr1^tm2Ltz/Cnr1^tm2.1Ltz Neurod6^tm1(cre)Kan	MGI:5524013
cn2	Nedd4^tm3.1Bros/Nedd4^tm3.1Bros Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129 * C57BL/6 * C57BL/6N * SJL	MGI:4836485
cn3	Afdn^tm1.1Lfr/Afdn^tm1.1Lfr Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129 * C57BL/6 * SJL	MGI:5308215
cn4	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129P2/OlaHsd	MGI:3055716
cn5	Nrg1^tm1Fej/Nrg1^tm1Fej Neurod6^tm1(cre)Kan/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3835559
cn6	Mapt^tm2Arbr/Mapt⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Trim67^tm1.1Slgu/Trim67^tm1.1Slgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6259603
cn7	Dab1^tm1.1Mull/Dab1^tm1.1Mull Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5141432
cn8	Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl	MGI:3758333
cn9	Neurod6^tm1(cre)Kan/Neurod6⁺ Pik3r4^mbe/Pik3r4^tm1.1Mpnd	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C3H/HeH * C57BL/6	MGI:6331081
cn10	Crhr1^tm2Wrst/Crhr1^tm2Wrst Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J	MGI:5294458
cn11	Cul3^tm1Jdsr/Cul3^tm1Jdsr Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA	MGI:6449726
cn12	Cul3^tm1Jdsr/Cul3⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA	MGI:6449730
cn13	Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:5307061
cn14	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac	MGI:5513847
cn15	Neurod6^tm1(cre)Kan/Neurod6⁺ Prkg1^tm2Naw/Prkg1^tm2.1Naw	involves: 129S1/Sv * 129X1/SvJ	MGI:2668663
cn16	Arhgap33^tm1.1Wbm/Arhgap33^tm1.1Wbm Cdc42^tm1Brak/Cdc42⁺ Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5431235
cn17	Smarcc2^tm1.1Stoy/Smarcc2^tm1.1Stoy Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5504446
cn18	Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi} Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:6275615
cn19	Plp1^{tm1c(EUCOMM)Wtsi}/Y Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:6160754
cn20	Lhx2^tm1.1Ddmo/Lhx2^tm1.1Ddmo Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4399059
cn21	Itgb8^tm1Lfr/Itgb8^tm2Lfr Neurod6^tm1(cre)Kan/Neurod6⁺	involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3609115
cn22	Lmo4^tm1Gng/Lmo4^tm1Gng Neurod6^tm1(cre)Kan/?	involves: 129X1/SvJ	MGI:3689431

Allelic Composition	Cnr1^tm2Ltz/Cnr1^tm2.1Ltz Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	B6.Cg-Cnr1^tm2Ltz/Cnr1^tm2.1Ltz Neurod6^tm1(cre)Kan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1^tm2.1Ltz mutation (0 available); any Cnr1 mutation (42 available)
Cnr1^tm2Ltz mutation (1 available); any Cnr1 mutation (42 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:199647 )

• in kainic acid treated mice but not as severely as in Cnr1^tm2Ltz homozygotes

behavior/neurological

behavior/neurological phenotype ( J:199647 )

N	• mice spend normal amounts of time in the open arms of an elevated plus maze and the light compartment in a light-dark test • mice exhibit normal susceptibility to kainic acid-induced seizures

abnormal cued conditioning behavior ( J:199647 )

• mice exhibit impaired extinction of cued conditioning response with a more sustained conditioned freezing response

• Background Sensitivity: however, cued conditioning is normal

nervous system

decreased synaptic depression ( J:199647 )

• reduced depolarization-induced suppression of GABAergic inhibitory postsynaptic currents in CA1 and basolateral amygdala neurons

• depolarization-induced suppression of glutamatergic excitatory postsynaptic currents in basolateral amygdala neurons has a prolonged time course

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:199647 )

• in kainic acid treated mice but not as severely as in Cnr1^tm2Ltz homozygotes

Allelic Composition	Nedd4^tm3.1Bros/Nedd4^tm3.1Bros Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4^tm3.1Bros mutation (0 available); any Nedd4 mutation (116 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:164745 )

N	• cerebellum size is normal

abnormal cerebral hemisphere morphology ( J:164745 )

• small

thin cerebral cortex ( J:164745 )

abnormal dendrite morphology ( J:164745 )

• dendrite extent and branching on CA1 region neurons are reduced compared to in wild-type mice

Allelic Composition	Afdn^tm1.1Lfr/Afdn^tm1.1Lfr Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Afdn^tm1.1Lfr mutation (0 available); any Afdn mutation (84 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:179366 )

• decrease in the densities of alpha-catenin, beta-N-catenin and EphB receptor puncta

• lower density of excitatory synapses in the CA1- stratum radiatum

• increase in average presynaptic terminal area in the CA1- stratum radiatum

abnormal hippocampus pyramidal cell morphology ( J:179366 )

• display a 43% decrease in spine density

ectopic hippocampus pyramidal cells ( J:179366 )

• a small number of CA1 pyramidal cell bodies are mislocalized to the stratum oriens (10%) or stratum radiatum (5%)

abnormal synapse morphology ( J:179366 )

• lower density of excitatory synapses in the CA1- stratum radiatum

• increase in average presynaptic terminal area in the CA1- stratum radiatum

abnormal excitatory postsynaptic potential ( J:179366 )

• lower field EPSPs in the CA1 region of the hippocampus

• however, the evoked fiber volley amplitude as a function of stimulus intensity is similar to controls indicating mutants have normal numbers of Schaffer collateral axons innervating CA1

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺ Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:92789 )

• mutants are born alive but die within the first day

nervous system

abnormal cerebral cortex morphology ( J:92789 )

• at E14.5, large numbers of apoptotic cells can be seen in the cre-expressing neuronal layer, in contrast no apoptotic cells are seen in controls

• at E16.5, the cortex is filled with many apoptotic cells and at E18.5 the cortex is highly degenerated and thin with abnormal layering and a wavelike structure

Allelic Composition	Nrg1^tm1Fej/Nrg1^tm1Fej Neurod6^tm1(cre)Kan/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Nrg1^tm1Fej mutation (0 available); any Nrg1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:145464 )

N	• fully viable and comparable to wild-type controls • cortex and hippocampus appear normal morphologically and immunohistochemically

Allelic Composition	Mapt^tm2Arbr/Mapt⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Trim67^tm1.1Slgu/Trim67^tm1.1Slgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2Arbr mutation (1 available); any Mapt mutation (430 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Trim67^tm1.1Slgu mutation (1 available); any Trim67 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased corpus callosum size ( J:266702 )

• thinner

Allelic Composition	Dab1^tm1.1Mull/Dab1^tm1.1Mull Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1.1Mull mutation (0 available); any Dab1 mutation (79 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:174747 )

• at E16.5, neuron layers is defective compared to in control mice

abnormal telencephalon development ( J:174747 )

• the preplate fails to split unlike in control mice

abnormal cortical marginal zone morphology ( J:174747 )

• at E16.5, mice lack the marginal zone unlike control mice

absent subplate ( J:174747 )

• at E16.5

cellular

abnormal neuronal migration ( J:174747 )

• at E16.5, neuron layers is defective compared to in control mice

Allelic Composition	Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnr1^tm1.2Ltz mutation (1 available); any Cnr1 mutation (42 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:122066 )

• 30 mg/kg kainic acid induces stronger seizures than in wild-type mice

abnormal nervous system development ( J:171771 )

• misrouted thalamocortical axons (TCAs) are observed in mutants but not in controls, similar to the complete Cnr1^tm1.1Ltz total null animals at E16.5

abnormal axon fasciculation ( J:171771 )

• deficits in fasciculation at E16.5 are similar to those observed in Cnr1^tm1.1Ltz total null animals at E16.5

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:122066 )

• 30 mg/kg kainic acid induces stronger seizures than in wild-type mice

abnormal response to novel object ( J:179495 )

• mutants eat less than controls on the first day of a novel palatable food test, however they progressively increase their palatable food consumption over the next 4 days to a similar level as in controls

• mutants display a very limited physical interaction with a novel object, when the palatability component is removed

abnormal impulsive behavior control ( J:179495 )

• mutants take more time to approach and eat novel food on the first exposure compared to wild-type mice, indicating increased behavioral inhibition in the approach of novel palatable food

• mutants exhibit an increase in both the latencies of contact with the novel food item and to displace the novel object

cellular

abnormal axon fasciculation ( J:171771 )

• deficits in fasciculation at E16.5 are similar to those observed in Cnr1^tm1.1Ltz total null animals at E16.5

Allelic Composition	Neurod6^tm1(cre)Kan/Neurod6⁺ Pik3r4^mbe/Pik3r4^tm1.1Mpnd
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C3H/HeH * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Pik3r4^mbe mutation (0 available); any Pik3r4 mutation (62 available)
Pik3r4^tm1.1Mpnd mutation (1 available); any Pik3r4 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus pyramidal cell layer ( J:258027 )

• pyramidal cell layer is fractured

ectopic hippocampus pyramidal cells ( J:258027 )

• increase in the number of ectopic pyramidal cells in the stratum oriens layer

abnormal hippocampus stratum oriens morphology ( J:258027 )

• the stratum oriens layer contains ectopic pyramidal cells

Allelic Composition	Crhr1^tm2Wrst/Crhr1^tm2Wrst Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1^tm2Wrst mutation (0 available); any Crhr1 mutation (28 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:176339 )

N	• mice exhibit normal behavior in a forced swim test and auditory fear conditioning

decreased anxiety-related response ( J:176339 )

• in a dark-light box, elevated plus maze, and novel object exploration tests

hyperactivity ( J:176339 )

nervous system

abnormal CNS synaptic transmission ( J:176339 )

• mice exhibit increased corticosterone-releasing hormone (CRH)-evoked excitatory field potentials on glutamatergic neurons compared with control mice

• CRH fails to enhance propagation of neuronal activity from hippocampal input region and CA1 input compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:176339 )

N	• mice exhibit normal basal and stress-induced corticosterone levels

Allelic Composition	Cul3^tm1Jdsr/Cul3^tm1Jdsr Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3^tm1Jdsr mutation (1 available); any Cul3 mutation (51 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Tg(Thy1-EGFP)MJrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:292173 )

absent corpus callosum ( J:292173 )

abnormal hippocampus morphology ( J:292173 )

• deformed hippocampus

abnormal stratification in cerebral cortex ( J:292173 )

thin cerebral cortex ( J:292173 )

mortality/aging

preweaning lethality ( J:292173 )

• mice die before age P17

growth/size/body

decreased body size ( J:292173 )

Allelic Composition	Cul3^tm1Jdsr/Cul3⁺ Neurod6^tm1(cre)Kan/Neurod6⁺ Tg(Thy1-EGFP)MJrs/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:292173 )

• fewer entries into and time spent in open arms in elevated plus maze test

• normal total distance travelled and time spent in closed arms in elevated plus maze test

increased thigmotaxis ( J:292173 )

• less time spent in center in open field test

• normal distance traveled in open field test

abnormal response to social novelty ( J:292173 )

• reduced social preference index when introduced to novel mouse and novel inanimate object in three-chamber test

• reduced social preference index when introduced to novel mouse and known mouse in three-chamber test

nervous system

nervous system phenotype ( J:292173 )

• normal cerebral cortex, corpus callosum and hippocampus morphology and brain weight

• normal neuron morphology in CA1 and hippocampal regions and in cerebral neocortex layers

• normal length and complexity of apical and basal dendrites of hippocampal CA1 neurons

• normal resting membrane potential (RMP) in hippocampal CA1 pyramidal neurons

increased dendritic spine density ( J:292173 )

• increased number of spines on apical dendrites of hippocampal CA1 neurons

increased miniature excitatory postsynaptic current frequency ( J:292173 )

• increased mEPSC frequency in hippocampal CA1 pyramidal neurons

increased miniature inhibitory postsynaptic current frequency ( J:292173 )

• increased mIPSC frequency in hippocampal CA1 pyramidal neurons

mortality/aging

mortality/aging ( J:292173 )

N	• viable and normal lifespan

growth/size/body

growth/size/body region phenotype ( J:292173 )

N	• normal body size

reproductive system

reproductive system phenotype ( J:292173 )

• fertile

Allelic Composition	Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2b^tm1.1Jlbr mutation (0 available); any Grin2b mutation (99 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal suckling behavior ( J:178913 )

• at P0 a decrease in the number of rhythmic mouth suckling movements in response to stimulation with a feeding needle is seen

• lack of milk in the stomach at P0

increased locomotor activity ( J:178913 )

• increased spontaneous locomotion at P15-P21

social withdrawal ( J:178913 )

Allelic Composition	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2^tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:197912 )

N	• NMDAR-evoked excitatory postsynaptic current amplitude

reduced AMPA-mediated synaptic currents ( J:197912 )

• in CA1 pyramidal neurons, dentate gyrus, and layer 2/3 pyramidal neurons in the barrel cortex

Allelic Composition	Neurod6^tm1(cre)Kan/Neurod6⁺ Prkg1^tm2Naw/Prkg1^tm2.1Naw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Prkg1^tm2.1Naw mutation (0 available); any Prkg1 mutation (60 available)
Prkg1^tm2Naw mutation (0 available); any Prkg1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:84444 )

N	• unlike Prkg1^tm1Hfm homozygotes, conditional mutant mice have a normal life expectancy

nervous system

nervous system phenotype ( J:84444 )

N	• adult conditional mutant mice display no significant differences in baseline synaptic transmission relative to control littermates

reduced long-term potentiation ( J:84444 )

• adult (12-14 weeks of age) but not juvenile (3-4 weeks of age) conditional mutant mice display reduced hippocampal LTP after repetitive episodes of theta burst stimulation (TBS)

• the difference in LTP between adult conditional and control mice is abolished by anisomycin (a protein synthesis inhibitor), suggesting a defect in late-phase LTP

• however, both juvenile and adult conditional mutant mice show a normal LTP in response to a single episode of tetanic stimulation, regardless of whether a weak TBS or a strong tetanic stimulus is used

behavior/neurological

behavior/neurological phenotype ( J:84444 )

• despite a deficit in late-phase LTP, adult conditional mutant mice exhibit normal performance in hippocampus-dependent behavioral tests, i.e., contextual fear conditioning and spatial learning, with no significant differences in the freezing response to the conditioning context, in acquisition of a spatial searching strategy, or in storage and retrieval of spatial memory relative to control mice

cardiovascular system

cardiovascular system phenotype ( J:84444 )

N	• unlike Prkg1^tm1Hfm homozygotes, conditional mutant mice display no detectable cardiovascular abnormalities

digestive/alimentary system

digestive/alimentary phenotype ( J:84444 )

N	• unlike Prkg1^tm1Hfm homozygotes, conditional mutant mice display no detectable gastrointestinal abnormalities

Allelic Composition	Arhgap33^tm1.1Wbm/Arhgap33^tm1.1Wbm Cdc42^tm1Brak/Cdc42⁺ Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap33^tm1.1Wbm mutation (0 available); any Arhgap33 mutation (45 available)
Cdc42^tm1Brak mutation (0 available); any Cdc42 mutation (45 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal parietal lobe morphology ( J:185948 )

• significant improvement in parietal cortical thickness compared to mice homozygous for Arhgap33^tm1.1Wbm alone

Allelic Composition	Smarcc2^tm1.1Stoy/Smarcc2^tm1.1Stoy Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Smarcc2^tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:197141 )

N	• the number of cortical progenitors and neuronal production is normal

Allelic Composition	Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi} Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cic^{tm1c(KOMP)Wtsi} mutation (1 available); any Cic mutation (98 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased cerebral cortex cell number ( J:240674 )

• mice show a reduction in the number of cells expressing CUX1 and SATB2 in cortical layers 2-4

Allelic Composition	Plp1^{tm1c(EUCOMM)Wtsi}/Y Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Plp1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Plp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:245100 )

N	• no APP+axonal spheroids, microgliosis, astrogliosis, or increase in T-lymphocytes are seen in the hippocampal fimbria at 26 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	hereditary spastic paraplegia 2	DOID:0110773	OMIM:312920	J:245100

Allelic Composition	Lhx2^tm1.1Ddmo/Lhx2^tm1.1Ddmo Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2^tm1.1Ddmo mutation (0 available); any Lhx2 mutation (12 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:154611 )

N	• mice exhibit normal development of the piriform cortex

Allelic Composition	Itgb8^tm1Lfr/Itgb8^tm2Lfr Neurod6^tm1(cre)Kan/Neurod6⁺
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb8^tm1Lfr mutation (1 available); any Itgb8 mutation (44 available)
Itgb8^tm2Lfr mutation (1 available); any Itgb8 mutation (44 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:102190 )

• no hemorrhages or other defects are seen in the brain

Allelic Composition	Lmo4^tm1Gng/Lmo4^tm1Gng Neurod6^tm1(cre)Kan/?
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo4^tm1Gng mutation (0 available); any Lmo4 mutation (9 available)
Neurod6^tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

disorganized barrel cortex ( J:111629 )

• poorly differentiated and smaller than controls

• thalamocortical afferents fail to segregate into distinct terminal patches and are significantly smaller than controls

• barrel-like organization of layer IV neuronal cell bodies also lacking

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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