All Phenotypes Fn1<tm1Bwg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fn1^tm1Bwg
targeted mutation 1, Brigham and Women's Hospital
MGI:2668886

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn1^tm1Bwg/Fn1^tm1Bwg	involves: 129S4/SvJae * BALB/c * C57BL/6J	MGI:3056919
hm2	Fn1^tm1Bwg/Fn1^tm1Bwg	involves: 129S4/SvJae * C57BL/6	MGI:3046827
cx3	Fn1^tm1Bwg/Fn1^tm1Bwg Tg(RIP1-Tag)2Dh/0	involves: 129S4/SvJae * BALB/c * C57BL/6J	MGI:3056920
cx4	Apoe^tm1Bres/Apoe^tm1Bres Fn1^tm1Bwg/Fn1^tm1Bwg	involves: 129S4/SvJae * C57BL/6	MGI:3046828

Allelic Composition	Fn1^tm1Bwg/Fn1^tm1Bwg
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:93027 )

N	• no difference in tumor growth is seen after injection of C57BL/6 melanoma cells

cardiovascular system

cardiovascular system phenotype ( J:93027 )

N	• no difference in physiological or tumor angiogenesis is seen

Allelic Composition	Fn1^tm1Bwg/Fn1^tm1Bwg
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:90917 )

N	• wound healing and peripheral blood leukocyte counts are normal

normal phenotype

no abnormal phenotype detected ( J:90917 )

• homozygotes are healthy and fertile

Allelic Composition	Fn1^tm1Bwg/Fn1^tm1Bwg Tg(RIP1-Tag)2Dh/0
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)
Tg(RIP1-Tag)2Dh mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased carcinoma incidence ( J:93027 )

• the number of angiogenic islets and tumor progression are not different from Tg(RIP1-Tag)2Dh hemizygotes

cardiovascular system

cardiovascular system phenotype ( J:93027 )

N	• no difference in tumor angiogenesis is seen

Allelic Composition	Apoe^tm1Bres/Apoe^tm1Bres Fn1^tm1Bwg/Fn1^tm1Bwg
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Bres mutation (9 available); any Apoe mutation (158 available)
Fn1^tm1Bwg mutation (1 available); any Fn1 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:90917 )

• on a high fat high cholesterol diet double homozygous mutants have reduced lesion area compared to Apoe^tm1Bres homozygotes

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:90917 )

• the cholesterol content of foam cells increases less in response to acetylated LDL compared to Apoe^tm1Bres homozygotes

decreased circulating VLDL cholesterol level ( J:90917 )

• fasting VLDL cholesterol levels after maintenance on a high fat diet are decreased compared to Apoe^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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