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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tep1tm1Leah
targeted mutation 1, Lea Harrington
MGI:2669947
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tep1tm1Leah/Tep1tm1Leah involves: 129P2/OlaHsd * C57BL/6J MGI:2670947
cx2
 		Parp4tm1Leah/Parp4tm1Leah
Tep1tm1Leah/Tep1tm1Leah 		involves: 129P2/OlaHsd * C57BL/6J MGI:3046851


Genotype
MGI:2670947
hm1
Allelic
Composition		 Tep1tm1Leah/Tep1tm1Leah
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tep1tm1Leah mutation (2 available); any Tep1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:84545 )
• homozygotes remain fertile through 7 generations
• telomerase activity not reduced in ES cells, testes, liver, kidney, lung, or thymus
• no telomerase reactivation in brain, skin, heart, or spleen
• telomere lengths were unaffected




Genotype
MGI:3046851
cx2
Allelic
Composition		 Parp4tm1Leah/Parp4tm1Leah
Tep1tm1Leah/Tep1tm1Leah
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Parp4tm1Leah mutation (2 available); any Parp4 mutation (90 available)
Tep1tm1Leah mutation (2 available); any Tep1 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:91080 )
• double homozygous mutants are viable with no significant change in telomerase activity or chromosome abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory