Phenotypes associated with this allele

• Allele Symbol: Btrc^tm1Kin
• Allele Name: targeted mutation 1, Kei-ichi Nakayama
• Allele ID: MGI:2669949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btrc^tm1Kin/Btrc^tm1Kin	involves: C57BL/6	MGI:2669950

Genotype
MGI:2669950

hm1

• Allelic Composition: Btrc^tm1Kin/Btrc^tm1Kin
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:84639 )

N • in spite of the abnormal accumulation of beta-catenin there is no increase in the incidence of cancer after 16 months of observation

cellular

abnormal cell morphology ( J:84639 )

• size of MEFs is substantially larger than that of wild-type MEFs

polyploidy ( J:84639 )

• percentage of polyploid cells is increased in mutant MEF cultures

increased fibroblast apoptosis ( J:84639 )

• MEFs grown in culture show an increase in frequency of apoptosis

decreased fibroblast proliferation ( J:84639 )

• MEFs grown in culture exhibit a reduced rate of proliferation compared to wild-type MEFs

hematopoietic system

abnormal lymphocyte morphology ( J:84639 )

• rate of proliferation of lymphocytes in response to various stimulants is reduced

immune system

abnormal lymphocyte morphology ( J:84639 )

• rate of proliferation of lymphocytes in response to various stimulants is reduced