Phenotypes associated with this allele

• Allele Symbol: Skil^tm1Spw
• Allele Name: targeted mutation 1, Sonia Pearson-White
• Allele ID: MGI:2670010
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Skil^tm1Spw/Skil^tm1Spw	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:2670927

Genotype
MGI:2670927

hm1

• Allelic Composition: Skil^tm1Spw/Skil^tm1Spw
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:84554 )

N • no significant increase in the incidence of somatic tumors up to 2 years of age

hematopoietic system

decreased T cell proliferation ( J:84554 )

• reduced T-cell activation in response to receptor stimulation

• proliferation was normal when stimulation bypassed early steps in activation

• IL-2 reverses proliferation defects

• effect probably due in part to reduced antagonism of TGF-beta signaling

enlarged spleen ( J:84554 )

• after 6 months of age when on a mixed background

immune system

decreased T cell proliferation ( J:84554 )

• reduced T-cell activation in response to receptor stimulation

• proliferation was normal when stimulation bypassed early steps in activation

• IL-2 reverses proliferation defects

• effect probably due in part to reduced antagonism of TGF-beta signaling

abnormal immune system cell morphology ( J:84554 )

• T-cell subpopulations from thymus and spleen are unchanged from wild-type

abnormal immune system organ morphology ( J:84554 )

enlarged spleen ( J:84554 )

• after 6 months of age when on a mixed background

cellular

decreased T cell proliferation ( J:84554 )

• reduced T-cell activation in response to receptor stimulation

• proliferation was normal when stimulation bypassed early steps in activation

• IL-2 reverses proliferation defects

• effect probably due in part to reduced antagonism of TGF-beta signaling

growth/size/body

enlarged spleen ( J:84554 )

• after 6 months of age when on a mixed background