Analysis Tools
immune system
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• homozygotes are viable and fertile with no major organ abnormalities or increased propensity for infections under pathogen-free conditions
• in response to i.p. challenge with 8 107 or 1 108 Candida albicans blastoconidia, homozygotes display no significant differences in survival rates or in blood, liver, and kidney fungal burdens at 3 days postinfection relative to similarly-infected wild-type controls
• in response to i.v. injection of 105 Plasmodium yoelii sporozoites, homozygotes show no significant differences in the levels of hepatic parasite RNA loads at 42 hrs postinfection relative to similarly-infected wild-type controls
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