Phenotypes associated with this allele

• Allele Symbol: Wasf2^tm1Fwa
• Allele Name: targeted mutation 1, Frederick W Alt
• Allele ID: MGI:2670143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wasf2^tm1Fwa/Wasf2^tm1Fwa	129S/SvEv-Wasf2^tm1Fwa	MGI:2670189

Genotype
MGI:2670189

hm1

• Allelic Composition: Wasf2^tm1Fwa/Wasf2^tm1Fwa
• Genetic Background: 129S/SvEv-Wasf2^tm1Fwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84642 )

• death between E12 and E12.5

cardiovascular system

hemorrhage ( J:84642 )

• no cardiac abnormalities were observed; however, hemorrhaging throughout the body was noted in some embryos

embryo

decreased embryo size ( J:84642 )

• severe growth retardation

abnormal embryonic tissue morphology ( J:84642 )

• embryos showed external abnormalities of the head, facial structures, and posterior limbs as well as variable abnormalities in body conformation

• notably, placental tissue appeared normal, indicating lethality was not due to a placental defect

abnormal somite development ( J:84642 )

• aberrant cellular organization of the caudal somites

growth/size/body

decreased embryo size ( J:84642 )

• severe growth retardation

liver/biliary system

liver/biliary system phenotype ( J:84642 )

N • normal organogenesis of the fetal liver

nervous system

abnormal brain ventricle morphology ( J:84642 )

• disruption of the symmetry and size of the ventricles of the forebrain and hindbrain, possibly due to a deficit of cerebrospinal fluid pressure

• no neural tube abnormalities were observed