All Phenotypes Itga2b<tm1(GFP/cre)Emam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itga2b^{tm1(GFP/cre)Emam}
targeted mutation 1, Nikla R Emambokus
MGI:2670210

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam}	involves: 129S6/SvEvTac * C57BL/6	MGI:2670217
cn2	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam} Rhoa^tm1Csab/Rhoa^tm1Csab Tg(ITGA2B)3Mako/0 Tg(Pf4-icre)Q3Rsko/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5548168

Allelic Composition	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^{tm1(GFP/cre)Emam} mutation (0 available); any Itga2b mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac

abnormal definitive hematopoiesis ( J:84564 )

• increase in the number of hematopoietic progenitor cells in the yolk sac, fetal liver, and bone marrow

• 1.5-fold increase in colony forming unit numbers and colony size from adult spleen cells

anemia ( J:84564 )

• observed in some mice due to a bleeding tendancy

thrombocytopenia ( J:84564 )

• thrombocytopenia is some mice

increased hematopoietic stem cell number ( J:84564 )

• 1.5- to 2-fold increase in hematopoietic progenitors in the adult bone marrow

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

homeostasis/metabolism

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

cellular

abnormal cell adhesion ( J:84564 )

• adhesion of bone marrow cells to fibronectin is impaired

embryo

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac

Allelic Composition	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam} Rhoa^tm1Csab/Rhoa^tm1Csab Tg(ITGA2B)3Mako/0 Tg(Pf4-icre)Q3Rsko/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^{tm1(GFP/cre)Emam} mutation (0 available); any Itga2b mutation (45 available)
Rhoa^tm1Csab mutation (0 available); any Rhoa mutation (73 available)
Tg(ITGA2B)3Mako mutation (0 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:204459 )

• cultured megakaryocytes derived from fetal liver E13.5 exhibit altered ploidy distribution (modal ploidy 16N compared with normal 2N) and larger size compared with control cells

• megakaryocytes are stiffer than in control cells

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

decreased megakaryocyte cell number ( J:204459 )

cellular

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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