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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp8a2agil
agitans-like
MGI:2670333
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atp8a2agil/Atp8a2agil C3H/HeJ-Atp8a2agil/GrsrJ MGI:2670340


Genotype
MGI:2670340
hm1
Allelic
Composition
Atp8a2agil/Atp8a2agil
Genetic
Background
C3H/HeJ-Atp8a2agil/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp8a2agil mutation (1 available); any Atp8a2 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dystrophic axons in Atp8a2agil/Atp8a2agil mice

mortality/aging
• homozygotes die by 3 weeks of age

behavior/neurological
• mice exhibit an unsteady, shaky, wobbly gait

growth/size/body
• by 15 days of age, homozygous mutant mice are smaller than their littermates

nervous system
• three of ten mutants had a few scatttered dystrophic axons and degenerating myelin sheaths (myelin figures) in spinal cord white matter; these changes are consistant with early degeneration of spinal cord white matter
• three of ten mutants had a few scatttered dystrophic axons in spinal cord white matter
• pathological screen of ten mutants and two controls, all at about 3 weeks of age, had slightly less deeply staining myelin in spinal cord stained with luxal fast blue





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory