mortality/aging
• homozygotes die by 3 weeks of age
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behavior/neurological
growth/size/body
• by 15 days of age, homozygous mutant mice are smaller than their littermates
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nervous system
• three of ten mutants had a few scatttered dystrophic axons and degenerating myelin sheaths (myelin figures) in spinal cord white matter; these changes are consistant with early degeneration of spinal cord white matter
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• three of ten mutants had a few scatttered dystrophic axons in spinal cord white matter
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• pathological screen of ten mutants and two controls, all at about 3 weeks of age, had slightly less deeply staining myelin in spinal cord stained with luxal fast blue
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