Phenotypes associated with this allele

• Allele Symbol: Tnfrsf25^tm1Mjo
• Allele Name: targeted mutation 1, Michael J Owen
• Allele ID: MGI:2670362
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo	involves: 129P2/OlaHsd	MGI:2670363
cx2	Rag1^tm1Mom/Rag1^tm1Mom Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3698843
cx3	Tg(TcraH-Y,TcrbH-Y)71Vbo/0 Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3698842

Genotype
MGI:2670363

hm1

• Allelic Composition: Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased T cell apoptosis ( J:84536 )

• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls

enlarged thymus ( J:84536 )

• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%

increased thymocyte number ( J:84536 )

• small but significant increase in total number of thymocytes is seen compared to heterozygous controls

abnormal negative T cell selection ( J:84536 )

• induction of DP thymocytes by anti-CD3, suggesting that negative selection is impaired by deficiency

immune system

decreased T cell apoptosis ( J:84536 )

• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls

enlarged thymus ( J:84536 )

• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%

increased thymocyte number ( J:84536 )

• small but significant increase in total number of thymocytes is seen compared to heterozygous controls

abnormal negative T cell selection ( J:84536 )

• induction of DP thymocytes by anti-CD3, suggesting that negative selection is impaired by deficiency

cellular

decreased T cell apoptosis ( J:84536 )

• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls

endocrine/exocrine glands

enlarged thymus ( J:84536 )

• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%

increased thymocyte number ( J:84536 )

• small but significant increase in total number of thymocytes is seen compared to heterozygous controls

Genotype
MGI:3698843

cx2

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

hematopoietic system

abnormal T cell differentiation ( J:84536 )

• thymocyte development is arrested at the CD25+CD44- double negative (DN) stage

immune system

abnormal T cell differentiation ( J:84536 )

• thymocyte development is arrested at the CD25+CD44- double negative (DN) stage

Genotype
MGI:3698842

cx3

• Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/0; Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

hematopoietic system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

immune system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

endocrine/exocrine glands

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females