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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Thratm3Jas
targeted mutation 1, Jacques Samarut
MGI:2670368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Thratm3Jas/Thratm3Jas involves: 129 MGI:2670421


Genotype
MGI:2670421
hm1
Allelic
Composition
Thratm3Jas/Thratm3Jas
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thratm3Jas mutation (0 available); any Thra mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• increase in the number of goblet cells in the ileum, however no other morphological abnormalities in the intestine
• enterocyte sucrase enzyme activity is decreased to less than 35% of wild-type
• administration of T3 to induce hyperthyroidism stimulates higher proliferation of crypt cells compared to wild-type, despite similar blood concentrations of T3

homeostasis/metabolism
• enterocyte sucrase enzyme activity is decreased to less than 35% of wild-type

cellular
• increase in the number of goblet cells in the ileum, however no other morphological abnormalities in the intestine
• administration of T3 to induce hyperthyroidism stimulates higher proliferation of crypt cells compared to wild-type, despite similar blood concentrations of T3





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory