All Phenotypes Rora<tmgc26> MGI Mouse

• mice begin to die at P12 and fewer than expected are present at weaning (J:171777)

• survival at P21 is less than in Rora^sg homozygotes (J:171777)

• radial glia are abnormally distributed in the cerebellar cortex compared to in wild-type mice

• radial glia development is delayed compared to in wild-type mice

abnormal neuron proliferation ( J:171777 )

• at P4 and P8, cells in the external granule layer exhibit reduced proliferation compared to in wild-type mice

• however, proliferation is normal by P12

• at P4, granule cell progenitors exhibit reduced proliferation compared to in wild-type mice

• molecular layer interneurons fail to survive unlike in wild-type mice

• however, generation of interneurons and population of the molecular layer is normal

abnormal cerebellum morphology ( J:81149 )

reduced cerebellar foliation ( J:171777 )

• rudimentary foliation

• the external granule layer persists until at least P20 unlike in wild-type mice

abnormal Purkinje cell morphology ( J:171777 )

• Purkinje cells are multilayered and small with smaller and less compared dendrites compared to in wild-type mice

decreased Purkinje cell size ( J:171777 )

ectopic Purkinje cell ( J:171777 )

• with ectopic Purkinje cells

ectopic cerebellar granule cells ( J:171777 )

absent cerebellar granule layer ( J:81149 )

• thin with ectopic granule cells

thin cerebellar molecular layer ( J:171777 )

small cerebellum ( J:171777 )

• diminutive at P21

• at P21, cerebellar weight is less than in Rora^sg homozygotes

ataxia ( J:81149 , J:171777 )

hindlimb paralysis ( J:81149 , J:171777 )