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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ubash3btm1Jni
targeted mutation 1, James N Ihle
MGI:2670555
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ubash3btm1Jni/Ubash3btm1Jni involves: 129P2/OlaHsd * C57BL/6 MGI:2670900
cx2
 		Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni 		Not Specified MGI:3052004
cx3
 		Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni 		Not Specified MGI:3052005


Genotype
MGI:2670900
hm1
Allelic
Composition		 Ubash3btm1Jni/Ubash3btm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubash3btm1Jni mutation (0 available); any Ubash3b mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:79606 )
• homozygous mice were grossly indistinguishable from wild-type, developed normally, were healthy, and survived as long as wild-type
• no reproductive histological, blood chemistry, or immunological abnormalities




Genotype
MGI:3052004
cx2
Allelic
Composition		 Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubash3atm1Jni mutation (0 available); any Ubash3a mutation (33 available)
Ubash3btm1Jni mutation (0 available); any Ubash3b mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice
• this increased proliferation is more pronounced than in Cblbtm1Hua homozygotes
increased mature B cell number ( J:89761 )
• the percentage of mature IgM-IgD+ splenic and peripheral lymph node B cells is increased and the percentage of less mature IgM+IgD- B cells is decreased
increased splenocyte number ( J:89761 )
• the total number of splenocytes is increased 30-50% in mutants compared to wild-type mice

immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice
• this increased proliferation is more pronounced than in Cblbtm1Hua homozygotes
increased mature B cell number ( J:89761 )
• the percentage of mature IgM-IgD+ splenic and peripheral lymph node B cells is increased and the percentage of less mature IgM+IgD- B cells is decreased
increased splenocyte number ( J:89761 )
• the total number of splenocytes is increased 30-50% in mutants compared to wild-type mice
abnormal cytokine secretion ( J:89761 )
• antigen stimulated cytokine secretion is increased in cultured mutant thymocytes compared to wild-type cultures
increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )
• the incidence and severity of experimental autoimmune encephalomyelitis is markedly increased with 20% of mutants dying compared to 4% of wild-type mice
• double homozygotes are also more susceptible to this disease than Cblbtm1Hua homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is increased 10 fold in response to antigen compared to wild-type mice
• this increased proliferation is more pronounced than in Cblbtm1Hua homozygotes




Genotype
MGI:3052005
cx3
Allelic
Composition		 Cblbtm1Hua/Cblbtm1Hua
Ubash3btm1Jni/Ubash3btm1Jni
Ubash3atm1Jni/Ubash3atm1Jni
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cblbtm1Hua mutation (0 available); any Cblb mutation (58 available)
Ubash3atm1Jni mutation (0 available); any Ubash3a mutation (33 available)
Ubash3btm1Jni mutation (0 available); any Ubash3b mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes
increased susceptibility to experimental autoimmune encephalomyelitis ( J:89761 )
• the incidence and severity of experimental autoimmune encephalomyelitis is increased similar to the increase seen in Elf1tm1Jni Ubash3atm1Jni double homozygotes

hematopoietic system
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes

cellular
increased T cell proliferation ( J:89761 )
• single positive T cell proliferation is synergistically increased in response to antigen compared to either Elf1tm1Jni Ubash3atm1Jni double homozygotes or Cblbtm1Hua homozygotes




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory