About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt2atm1Thr
targeted mutation 1, Terence H Rabbitts
MGI:2670764
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lmo2tm2(cre)Thr/Lmo2+
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+ 		involves: 129S/SvEv MGI:2671953
cn2
 		Kmt2atm1Thr/Kmt2a+
Mllt3tm2Thr/Mllt3+
Tg(Lck-cre)1Thr/? 		involves: 129S/SvEv MGI:3720075
cn3
 		Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Tg(Lck-cre)1Thr/? 		involves: 129S/SvEv MGI:3720076


Genotype
MGI:2671953
cn1
Allelic
Composition		 Lmo2tm2(cre)Thr/Lmo2+
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Lmo2tm2(cre)Thr mutation (0 available); any Lmo2 mutation (31 available)
Mllt1tm1Thr mutation (0 available); any Mllt1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84518 )
• 100% of mutants either die or are sacrified due to ill health by 120 days of age

neoplasm
increased hemolymphoid system tumor incidence ( J:100794 )
• all mice develop hematological malignancies
• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes
increased leukemia incidence ( J:84518 , J:100794 )
• develop myeloid leukemias as early as 1.5 months of age (J:84518)
• leukemic cells invade the spleen and into peripheral organs such as liver and kidneys with perivascular deposits of tumor cells in liver and in between glomerili of kidney (J:84518)
• mice have myelo-proliferative-like myeloid leukemia (J:100794)

hematopoietic system
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

immune system
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

liver/biliary system

renal/urinary system

growth/size/body
enlarged spleen ( J:84518 , J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)




Genotype
MGI:3720075
cn2
Allelic
Composition		 Kmt2atm1Thr/Kmt2a+
Mllt3tm2Thr/Mllt3+
Tg(Lck-cre)1Thr/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Mllt3tm2Thr mutation (0 available); any Mllt3 mutation (31 available)
Tg(Lck-cre)1Thr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hemolymphoid system tumor incidence ( J:100794 )
• 18 of 20 mice develop hematopoeitic neoplasm that are either T cell or myeloid in origin
• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas
increased leukemia incidence ( J:100794 )
• mice have myelo-proliferative-like myeloid leukemia without circulating leukemic cells

hematopoietic system
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

immune system
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells
abnormal spleen red pulp morphology ( J:100794 )
• red and white pulp architecture is lost
abnormal spleen white pulp morphology ( J:100794 )
• red and white pulp architecture is lost

growth/size/body
enlarged spleen ( J:100794 )
• splenomeglia is caused by a repopulation of the spleen with malignant cells

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:100794 )
• mice develop small T cell lymphomas




Genotype
MGI:3720076
cn3
Allelic
Composition		 Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Tg(Lck-cre)1Thr/?
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Thr mutation (0 available); any Kmt2a mutation (135 available)
Mllt1tm1Thr mutation (0 available); any Mllt1 mutation (21 available)
Tg(Lck-cre)1Thr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:100794 )
N
• no hematological malignancies are observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory