Phenotypes associated with this allele

• Allele Symbol: Fes^tm1Pag
• Allele Name: targeted mutation 1, Peter A Greer
• Allele ID: MGI:2670783
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fes^tm1Pag/Fes^tm1Pag	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2672898
cx2	Fes^tm1Pag/Fes^tm1Pag Tg(MMTV-PyVT)634Mul/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3581867

Genotype
MGI:2672898

hm1

• Allelic Composition: Fes^tm1Pag/Fes^tm1Pag
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:84535 )

N • normal numbers of all blood cells in peripheral blood

N • normal number, proliferation and differentiation of hematopoietic progenitors in bone marrow

N • normal spleen weights as well as normal spleen morphology and histology

normal phenotype

no abnormal phenotype detected ( J:84535 )

• homozygotes are fertile, produce normal litter sizes, and analysis of all major organs shows no gross abnormalities

Genotype
MGI:3581867

cx2

• Allelic Composition: Fes^tm1Pag/Fes^tm1Pag; Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

neoplasm

decreased tumor latency ( J:98281 )

• tumor onset and initiation of the rapid growth phase of tumor development occur earlier compared to transgenic mice that are wild-type for Fes but later than in transgenic mice homozygous for Fes^tm2Pag