Phenotypes associated with this allele

• Allele Symbol: Tkt^tm1Jpi
• Allele Name: targeted mutation 1, Joram Piatigorsky
• Allele ID: MGI:2671068
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tkt^tm1Jpi/Tkt^tm1Jpi	involves: 129X1/SvJ * C57BL/6J	MGI:2671092
ht2	Tkt^tm1Jpi/Tkt^+	involves: 129X1/SvJ * C57BL/6J	MGI:2671091

Genotype
MGI:2671092

hm1

• Allelic Composition: Tkt^tm1Jpi/Tkt^tm1Jpi
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:78430 )

• homozygous embryos die at or before the morula stage

Genotype
MGI:2671091

ht2

• Allelic Composition: Tkt^tm1Jpi/Tkt⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

adipose tissue

decreased white adipose tissue amount ( J:78430 )

• average weight of the fat tissues in heterozygous mice was 22% of control weight

behavior/neurological

abnormal sexual interaction ( J:78430 )

♀ • infrequent mating noted in some females

cardiovascular system

decreased heart weight ( J:78430 )

• average weight of the heart in heterozygous mice was 85% of control weight

endocrine/exocrine glands

decreased testis weight ( J:78430 )

♂ • average weight of the testes in heterozygous mice was 67% of control weight

growth/size/body

decreased body weight ( J:78430 )

• mice were 60-64% smaller than wild-type littermates at 1 year of age

postnatal growth retardation ( J:78430 )

liver/biliary system

decreased liver weight ( J:78430 )

• average weight of the liver in heterozygous mice was 64% of control weight

renal/urinary system

decreased kidney weight ( J:78430 )

• average weight of the kidney in heterozygous mice was 82% of control weight

reproductive system

decreased testis weight ( J:78430 )

♂ • average weight of the testes in heterozygous mice was 67% of control weight

reduced fertility ( J:78430 )

• as judged by number of pups delivered to heterozygous females

vision/eye

microphthalmia ( J:78430 )

• small eye; average weight of the eyes in heterozygous mice was 93% of control weight

• however, corneas exhibited normal clarity and normal histology

nervous system

decreased brain weight ( J:78430 )

• average weight of the brain in heterozygous mice was 92% of control weight