Analysis Tools
homeostasis/metabolism
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• on a 1% cholic acid diet, mutants exhibit approximately 30% decrease in serum cholesterol level compared to wild-type
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• on a normal diet, bile acid pool size is increased by 1.6-fold in mutants
• on a 1% cholic acid (a bile acid) diet, bile acid pool size is decreased by 2-fold in mutants compared to wild-type
• on a 1% cholic acid diet, mutants show a less marked increase in the rate of bile acid excretion relative to wild-type
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• on a 1% cholic acid diet, serum bile acid concentration does not increase in mutants as much as in wild-type, resulting in a 2.7-fold higher concentration in wild-type than in mutants
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• on a normal diet, total serum bile acid concentration is 2.3-fold greater than in wild-type
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• a 1% cholic acid diet has a smaller effect on reducing hepatic triglyceride content than in wild-type, resulting in a 2.3-fold higher level in mutants than wild-type
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growth/size/body
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• although mutants exhibit normal weight gain and growth on a normal control diet and a similar decrease in body weight in the first two days on a 1% cholic acid diet as wild-type mice, they continue to show a decrease in body weight after the first 2 days on the cholic acid diet that is not observed in wild-type
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liver/biliary system
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• a 1% cholic acid diet has a smaller effect on reducing hepatic triglyceride content than in wild-type, resulting in a 2.3-fold higher level in mutants than wild-type
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