All Phenotypes Nr1d1<tm1Schb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr1d1^tm1Schb
targeted mutation 1, Ueli Schibler
MGI:2671157

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1d1^tm1Schb/Nr1d1^tm1Schb	involves: 129S2/SvPas	MGI:4361271
hm2	Nr1d1^tm1Schb/Nr1d1^tm1Schb	involves: 129S2/SvPas * C57BL/6J	MGI:3815321
cx3	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp Nr1d1^tm1Schb/Nr1d1^tm1Schb	involves: 129S2/SvPas	MGI:5494570
cx4	Fbxl3^Ovtm/Fbxl3^Ovtm Nr1d1^tm1Schb/Nr1d1^tm1Schb	involves: 129S2/SvPas * BTBR	MGI:5494574

Allelic Composition	Nr1d1^tm1Schb/Nr1d1^tm1Schb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1d1^tm1Schb mutation (1 available); any Nr1d1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:153064 )

• at the end of the light phase

increased circulating LDL cholesterol level ( J:153064 )

• at the end of the light phase

abnormal bile salt homeostasis ( J:153064 )

• mice exhibit a decrease in primary and secondary bile acids cholate and deoxycholate compared with wild-type mice

decreased liver cholesterol level ( J:153064 )

• at the end of the light phase

decreased liver triglyceride level ( J:153064 )

• at the end of the light phase

liver/biliary system

decreased liver cholesterol level ( J:153064 )

• at the end of the light phase

decreased liver triglyceride level ( J:153064 )

• at the end of the light phase

Allelic Composition	Nr1d1^tm1Schb/Nr1d1^tm1Schb
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1d1^tm1Schb mutation (1 available); any Nr1d1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

shortened circadian behavior period ( J:78197 )

• under both constant darkness (DD) and constant light (LL) conditions, the average period length is significantly shorter in mutants

• the distribution of period lengths is more scattered in mutants than wild-type

advanced circadian behavior phase ( J:78197 )

• light pulses delivered at CT 22 provoke dramatic phase advances in mutants compared to wild-type

• large phase advances are seen only in mutants kept in DD for longer than seven days

• the difference in phase-shifting is limited to the second half of the night

reproductive system

decreased litter size ( J:78197 )

• litter size of homozygous females is only about half that seen in wild-type females

Allelic Composition	Fbxl3^tm1.1Ljp/Fbxl3^tm1.1Ljp Nr1d1^tm1Schb/Nr1d1^tm1Schb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3^tm1.1Ljp mutation (0 available); any Fbxl3 mutation (43 available)
Nr1d1^tm1Schb mutation (1 available); any Nr1d1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194250 )

N	• circadian rhythm is near normal at 23.7 hours

abnormal circadian behavior period ( J:194250 )

• unstable onset of activity

• about 10% of double homozygotes become arrhythmic after 2-3 weeks of constant darkness

Allelic Composition	Fbxl3^Ovtm/Fbxl3^Ovtm Nr1d1^tm1Schb/Nr1d1^tm1Schb
Genetic Background	involves: 129S2/SvPas * BTBR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3^Ovtm mutation (1 available); any Fbxl3 mutation (43 available)
Nr1d1^tm1Schb mutation (1 available); any Nr1d1 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194250 )

N	• 23.7 hour circadian rhythm is relatively normal

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